About: Troxacitabine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Troxacitabine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Troxacitabine
UMLS_CUI
  • C0877874
CAS_Registry
  • 145918-75-8
In_Clinical_Trial_For
  • Chronic myelogenous leukemia
FDA_UNII_Code
  • 60KQZ0388Y
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug being studied for use as an anticancer agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43646
PDQ_Closed_Trial_Search_ID
  • 43646
Chemical_Formula
  • C8H11N3O4
Legacy_Concept_Name
  • Troxacitabine
FULL_SYN
  • TROXACITABINEPTFDA60KQZ0388Y
  • TroxacitabinePTNCI
  • 2(1H)-Pyrimidinone, 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-SNNCI
  • troxacitabinePTNCI-GLOSSCDR0000046760
  • L-OddcCNNCI
  • BCH-4556CNNCI
  • TroxatylBRNCI
DEFINITION
  • A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain during DNA replication, troxacitabine stops DNA polymerization due to its unnatural L-configuration, in contrast to the normal nucleotides with D-configuration. As a result, this agent terminates DNA synthesis upon incorporated into DNA molecules, and consequently interrupts tumor cell proliferation.NCI
code
  • C1438
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