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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Efaproxiral
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Efaproxiral
NSC_Code
  • 950116
UMLS_CUI
  • C0080719
CAS_Registry
  • 131179-95-8
FDA_UNII_Code
  • J81E81G364
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that may increase the effectiveness of radiation therapy.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42624
PDQ_Closed_Trial_Search_ID
  • 42624
Chemical_Formula
  • C20H23NO4
Legacy_Concept_Name
  • RSR-13
FULL_SYN
  • EfaproxiralPTNCI
  • RSR13CNNCI
  • EfaproxynSYNCI
  • efaproxiralPTNCI-GLOSSCDR0000269877
  • RSR13PTNCI-GLOSSCDR0000045527
  • 2-(4-(((3,5-Dimethylanilino)Carbonyl)Methyl)Phenoxy)-2-Methylpropionic AcidSNNCI
  • RSR-13CNNCI
  • 2-DacmppSYNCI
  • EFAPROXIRALPTFDAJ81E81G364
DEFINITION
  • A synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. (NCI04)NCI
DesignNote
  • 5-11-04 FDA advisory committee advised not to approve
code
  • C1435
sameAs
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