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AttributesValues
rdf:type
rdfs:label
  • Cladribine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Cladribine
NSC_Code
  • 105014
  • 105014-F
UMLS_CUI
  • C0092801
CAS_Registry
  • 4291-63-8
Accepted_Therapeutic_Use_For
  • Acute myeloid leukemia; Chronic lymphocytic leukemia; Cutaneous T-cell lymphoma; Hairy cell leukemia; Langerhans cell histiocytosis; Non-Hodgkins lymphoma; Waldenstroms macroglobulinemia
In_Clinical_Trial_For
  • Chronic lymphocytic leukemia; Hairy cell leukemia
FDA_UNII_Code
  • 47M74X9YT5
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called antimetabolites.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41184
PDQ_Closed_Trial_Search_ID
  • 41184
Chemical_Formula
  • C10H12ClN5O3
Legacy_Concept_Name
  • Cladribine
CHEBI_ID
  • CHEBI:567361
FULL_SYN
  • 2-ChlorodeoxyadenosineSNNCI
  • cladribinePTNCI-GLOSSCDR0000045341
  • 2-Chloro-2-DeoxyadenosineSNNCI
  • CdAABNCI
  • 2CDAABNCI
  • 2-CdAABNCI
  • LeustatFBNCI
  • CLADRIBINEPTFDA47M74X9YT5
  • RWJ-26251CNNCI
  • LeustatinBRNCI
  • CladribinaSYNCI
  • CladribinePTNCI
  • LeustatineFBNCI
DEFINITION
  • A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)NCI
DesignNote
code
  • C1336
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