About: Saperconazole     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Saperconazole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Saperconazole
UMLS_CUI
  • C0074037
CAS_Registry
  • 110588-57-3
FDA_UNII_Code
  • R2I5PI29CA
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41937
PDQ_Closed_Trial_Search_ID
  • 41937
Chemical_Formula
  • C35H38F2N8O4
Legacy_Concept_Name
  • Saperconazole
FULL_SYN
  • SAPERCONAZOLEPTFDAR2I5PI29CA
  • SaperconazolePTNCI
  • R66905CNNCI
  • (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-oneSNNCI
  • R 66905CNNCI
DEFINITION
  • A synthetic broad-spectrum fluorinated triazole with potential antifungal activity. Saperconazole preferentially inhibits fungal cytochrome P450 sterol 14 alpha-demethylase (CYP51), an enzyme responsible for the conversion of lanosterol to ergosterol, an important component of the fungal cell membrane. Enzyme inhibition by this agent leads to a decrease in ergosterol pool that distresses synthesis of fungal cell membrane, thereby increases cell membrane permeability, and promotes loss of essential intracellular elements. This ultimately causes fungal cell lysis and death.NCI
code
  • C1221
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