About: Miltefosine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Miltefosine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Organophosphorus Compound
Preferred_Name
  • Miltefosine
UMLS_CUI
  • C0068006
CAS_Registry
  • 58066-85-6
Accepted_Therapeutic_Use_For
  • Skin metastasis of breast cancer
FDA_UNII_Code
  • 53EY29W7EC
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41212
PDQ_Closed_Trial_Search_ID
  • 41212
Chemical_Formula
  • C21H46NO4P
Legacy_Concept_Name
  • Miltefosine
FULL_SYN
  • HexadecylphosphocholinePTDCP20314
  • MiltefosinaSYNCI
  • MiltefosinePTNCI
  • MiltefosinumSYNCI
  • HexadecylphosphocholineSYNCI
  • 2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner SaltSNNCI
  • Choline Phosphate Hexadecyl Ester, Hydroxide, Inner SaltSYNCI
  • MiltexFBNCI
  • n-HexadecylphosphorylcholineSNNCI
  • D-18506CNNCI
  • Hexadecyl 2-(N,N,N-trimethylamino)ethyl PhosphateSNNCI
  • MILTEFOSINEPTFDA53EY29W7EC
  • MiltefosinSYNCI
DEFINITION
  • An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04)NCI
code
  • C1170
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