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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mitozolomide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Mitozolomide
NSC_Code
  • 353451
UMLS_CUI
  • C0066618
CAS_Registry
  • 85622-95-3
FDA_UNII_Code
  • E3U7286V3W
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 40221
PDQ_Closed_Trial_Search_ID
  • 40221
Chemical_Formula
  • C7H7ClN6O2
Legacy_Concept_Name
  • Mitozolomide
FULL_SYN
  • MITOZOLOMIDEPTFDAE3U7286V3W
  • MitozolomideSYDTPNSC0353451
  • MitozolomidePTNCI
  • imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxoSNNCI
  • AzolastoneSYDTPNSC0353451
  • Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo-SYDTPNSC0353451
  • AzolastoneBRNCI
DEFINITION
  • A prodrug of imidazotetrazine alkylating agent with antineoplastic property. Mitozolomide undergoes ring opening upon the nucleophilic attack at C-4 by an activated molecule of water within the major groove of DNA. The resulting bioactive mono-alkyltriazene species are capable of alkylating nucleophilic residues in the immediate vicinity such as N-7 and/or O-6 sites of guanine, thereby causes intra- or inter-stranded DNA cross-links and trigger apoptosis.NCI
code
  • C1166
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