About: Metoprine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Metoprine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Metoprine
NSC_Code
  • 19494
  • 7364
UMLS_CUI
  • C0066142
CAS_Registry
  • 7761-45-7
FDA_UNII_Code
  • 2L9RKX796Q
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39206
PDQ_Closed_Trial_Search_ID
  • 39206
Chemical_Formula
  • C11H10Cl2N4
Legacy_Concept_Name
  • Metoprine
FULL_SYN
  • BW 197USYDTPNSC0007364
  • DDMPABNCI
  • METOPRINEPTFDA2L9RKX796Q
  • BW 197UCNNCI
  • MetoprinePTNCI
DEFINITION
  • A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. (NCI04)NCI
code
  • C1161
http://linked.open...y/mesh/hasConcept
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