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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Leflunomide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Leflunomide
NSC_Code
  • 677411
UMLS_CUI
  • C0718644
CAS_Registry
  • 75706-12-6
FDA_UNII_Code
  • G162GK9U4W
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that works by inhibiting a cancer cell growth factor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42253
PDQ_Closed_Trial_Search_ID
  • 42253
Chemical_Formula
  • C12H9F3N2O2
Legacy_Concept_Name
  • Leflunomide
CHEBI_ID
  • CHEBI:6402
FULL_SYN
  • LeflunomideSYDTPNSC0677411
  • LeflunomidePTNCI
  • 4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-SNNCI
  • leflunomidePTNCI-GLOSSCDR0000045436
  • SU101SYNCI-GLOSSCDR0000046000
  • SU101CNNCI
  • AravaBRNCI
  • LEFLUNOMIDEPTFDAG162GK9U4W
DEFINITION
  • A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04)NCI
code
  • C1128
sameAs
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