About: Fadrozole Hydrochloride     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fadrozole Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Fadrozole Hydrochloride
UMLS_CUI
  • C0917743
CAS_Registry
  • 102676-31-3
  • 102676-96-0
FDA_UNII_Code
  • H0Q44H4ECQ
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41025
PDQ_Closed_Trial_Search_ID
  • 41025
Chemical_Formula
  • C14H13N3.HCl
Legacy_Concept_Name
  • Fadrozole_Hydrochloride
FULL_SYN
  • Fadrozole HydrochloridePTNCI
  • 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile MonohydrochloridePTDCP08932
  • FADROZOLE HYDROCHLORIDEPTFDAH0Q44H4ECQ
  • 4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile HydrochlorideSNNCI
  • AfemaFBNCI
  • ArensinFBNCI
  • CGS-16949ACNNCI
DEFINITION
  • The hydrochloride salt of the nonsteroidal aromatase inhibitor fadrozole with potential antineoplastic activity. Fadrozole specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively, the final step in estrogen biosynthesis; the reduction in estrogen levels may inhibit growth in estrogen-dependent cancers. Aromatase, a member of the cytochrome P-450 superfamily, is found in many tissues; overexpression has been linked to the development of preneoplastic and neoplastic changes in breast tissue.NCI
code
  • C1044
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