About: EphA2-targeting DOPC-encapsulated siRNA     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • EphA2-targeting DOPC-encapsulated siRNA
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • EphA2-targeting DOPC-encapsulated siRNA
NCI_META_CUI
  • CL436272
PDQ_Open_Trial_Search_ID
  • 733792
PDQ_Closed_Trial_Search_ID
  • 733792
FULL_SYN
  • siRNA-EphA2-DOPCSYNCI
  • EphA2-targeting DOPC-encapsulated siRNAPTNCI
DEFINITION
  • A liposomal formulation consisting of short-interfering RNAs (siRNAs) directed against ephrin type-A receptor 2 (EphA2) and encapsulated into 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) neutral liposomes, with potential antineoplastic activity. Upon internalization, EphA2-targeting DOPC-encapsulated siRNA can hybridize to EphA2 DNA and mRNA, thereby interfering with both the transcription and translation of EphA2, and thus inhibiting tumor cell growth. The cell-surface receptor EphA2, a member of the ephrin family of receptor tyrosine kinases (RTKs) involved in mammalian development, is overexpressed by a variety of different cancer cell types and plays an important role in tumor growth.NCI
code
  • C101889
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