About: CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells
NCI_META_CUI
  • CL435506
PDQ_Open_Trial_Search_ID
  • 729149
PDQ_Closed_Trial_Search_ID
  • 729149
FULL_SYN
  • CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte CellsPTNCI
  • CART-19 CellsSYNCI
DEFINITION
  • Allogeneic T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-4-1BB-expressing allogeneic T-lymphocyte cells direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.NCI
code
  • C101258
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