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  • Tabulka 14 Průměrné (% CV) farmakokinetické parametry pro interferon alfa-2b a ribavirin podávané ve více dávkách pediatrickým pacientům s chronickou hepatitidou C Parametr Ribavirin 15 mg/kg/den jako 2 dílčí dávky (n = 17) Interferon alfa-2b 3 mil. m.j./m2 3xtýdně (n = 54) Tmax (h) 1,9 (83) 5,9 (36) Cmax (ng/ml) 3 275 (25) 51 (48) AUC* 29 774 (26) 622 (48) Vypočítaná clearance l/hr/kg 0,27 (27) Nehodnoceno *AUC12 (ng.h/ml) pro ribavirin; AUC0-24 (IU.h/ml) pro interferon alfa-2b (cs)
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