About: Dabrafenib

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Dabrafenib mesylate is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. FDA approved on May 29, 2013. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5CAE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5CAF-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Gibney GT, Zager JS: Clinical development of dabrafenib in BRAF mutant melanoma and other malignancies. Expert Opin Drug Metab Toxicol. 2013 Jul;9(7):893-9. doi: 10.1517/17425255.2013.794220. Epub 2013 Apr 29. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23621583 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Dabrafenib = 8 hours; Hydroxy-dabrafenib = 10 hours; Carboxy-dabrafenib = 21-22 hours; Desmethyl-dabrafenib = 21- 22 hours. (en)
http://linked.open...ugbank/indication	Dabrafenib is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test. (en)
sameAs	Dabrafenib
Title	Dabrafenib (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08912/identifier/drugbank/DB08912 http://linked.opendata.cz/resource/drugbank/drug/DB08912/identifier/kegg-drug/D10064 http://linked.opendata.cz/resource/drugbank/drug/DB08912/identifier/national-drug-code-directory/0173-0847-08 http://linked.opendata.cz/resource/drugbank/drug/DB08912/identifier/wikipedia/Dabrafenib
http://linked.open...mechanismOfAction	Dabrafenib is an inhibitor of some mutated forms of BRAF kinases with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Dabrafenib also inhibits wild-type BRAF and CRAF kinases with IC50 values of 3.2 and 5.0 nM, respectively, and other kinases such as SIK1, NEK11, and LIMK1 at higher concentrations. Some mutations in the BRAF gene, including those that result in BRAF V600E, can result in constitutively activated BRAF kinases that may stimulate tumor cell growth. (en)
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/7994185 http://linked.opendata.cz/resource/drugbank/patent/8415345
http://linked.open...outeOfElimination	71% of the dose is excreted in feces. 23% of the dose is excreted in the urine as metabolites only. (en)
http://linked.open.../drugbank/synonym	Dabrafenib (en) GSK2118436a (en)
http://linked.open...drugbank/toxicity	Most common adverse reactions (≥20%) for dabrafenib are hyperkeratosis, headache, pyrexia, arthralgia, papilloma, alopecia, and palmar-plantar erythrodysesthesia syndrome. (en)
http://linked.open...umeOfDistribution	Apparent volume of distribution (Vd/F) = 70.3 L. Distribution to the brain is restricted because dabrafenib is a substrate and undergoes efflux by P-glycoprotein and breast cancer resistance protein. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/10-00%20
http://linked.open...k/foodInteraction	When taken with a fatty meal, Cmax and AUC decreased. Tmax is also prolonged compared to the fasted condition. (en)
http://linked.open...nk/proteinBinding	99.7% bound to human plasma protein. (en)
http://linked.open...ogy/drugbank/salt	(en)
foaf:page	http://www.drugs.com/tafinlar.html http://www.rxlist.com/tafinlar-drug.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5CB4-363D-11E5-9242-09173F13E4C5
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5CB9-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5CB6-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Dabrafenib
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5CC0-363D-11E5-9242-09173F13E4C5
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http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5CBF-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	After oral administration, median time to achieve peak plasma concentration (Tmax) is 2 hours. Mean absolute bioavailability of oral dabrafenib is 95%. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...rugbank/clearance	The apparent clearance of dabrafenib is 17.0 L/h after single dosing and 34.4 L/h after 2 weeks of twice daily dosing. (en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B5CC6-363D-11E5-9242-09173F13E4C5
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http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B5CC2-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5CC3-363D-11E5-9242-09173F13E4C5

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