About: CNS-5161

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	CNS 5161 is a blocker of the NMDA ion channel and has completed Phase IIa proof of concept clinical trials as a novel compound for the treatment of neuropathic pain. (en)
http://linked.open...generalReferences	# Biegon A, Gibbs A, Alvarado M, Ono M, Taylor S: In vitro and in vivo characterization of [3H]CNS-5161--a use-dependent ligand for the N-methyl-D-aspartate receptor in rat brain. Synapse. 2007 Aug;61(8):577-86. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17455246 # Walters MR, Bradford AP, Fischer J, Lees KR: Early clinical experience with the novel NMDA receptor antagonist CNS 5161. Br J Clin Pharmacol. 2002 Mar;53(3):305-11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11874394 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in migraine and cluster headaches, neuropathy (diabetic), and pain (acute or chronic). (en)
sameAs	CNS-5161
Title	CNS-5161 (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05824/identifier/bindingdb/50096974 http://linked.opendata.cz/resource/drugbank/drug/DB05824/identifier/chemspider/167230 http://linked.opendata.cz/resource/drugbank/drug/DB05824/identifier/drugbank/DB05824 http://linked.opendata.cz/resource/drugbank/drug/DB05824/identifier/pubchem-compound/192711
http://linked.open...mechanismOfAction	CNS 5161 is a selective and high affinity N-methyl-D-aspartate (NMDA) receptor antagonist with preferential binding to the activated form of the receptor. CNS 5161 also penetrates the brain well and can be used to label selectively brain NMDA receptors in vivo. A radioactive form of CNS 5161 may be used as an agent to monitor NMDA receptors in the human brain using Positron Emission Tomography ("PET") and "the significance of a selective, validated radiopharmaceutical agent suitable for detecting widespread as well as highly localized changes in the NMDA receptor in the living brain cannot be exaggerated". (en)
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