About: Vapreotide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description	Vapreotide is a synthetic octapeptide somatostatin analog. It was being studied for the treatment of cancer. (en)
http://linked.open...generalReferences	# Sarr MG: The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial. J Am Coll Surg. 2003 Apr;196(4):556-64; discussion 564-5; author reply 565. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12691930 # Vapreotide: BMY 41606, RC 160, Sanvar. Drugs R D. 2003;4(5):326-30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12952505 # Norman P: Vapreotide (Debipharm). IDrugs. 2000 Nov;3(11):1358-72. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16047258 # Betoin F, Ardid D, Herbet A, Aumaitre O, Kemeny JL, Duchene-Marullaz P, Lavarenne J, Eschalier A: Evidence for a central long-lasting antinociceptive effect of vapreotide, an analog of somatostatin, involving an opioidergic mechanism. J Pharmacol Exp Ther. 1994 Apr;269(1):7-14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7909563 # Girard PM, Goldschmidt E, Vittecoq D, Massip P, Gastiaburu J, Meyohas MC, Coulaud JP, Schally AV: Vapreotide, a somatostatin analogue, in cryptosporidiosis and other AIDS-related diarrhoeal diseases. AIDS. 1992 Jul;6(7):715-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1354449 # Stiefel F, Morant R: Vapreotide, a new somatostatin analogue in the palliative management of obstructive ileus in advanced cancer. Support Care Cancer. 1993 Jan;1(1):57-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7511473 # Betoin F, Eschalier A, Duchene-Marullaz P, Lavarenne J: Seven-day antinociceptive effect of a sustained release vapreotide formulation. Neuroreport. 1994 Jan 31;5(5):642-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7912964 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	30 minutes (en)
http://linked.open...ugbank/indication	For the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea. (en)
sameAs	Vapreotide Vapreotide
Title	Vapreotide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04894/identifier/chemspider/64425 http://linked.opendata.cz/resource/drugbank/drug/DB04894/identifier/drugbank/DB04894 http://linked.opendata.cz/resource/drugbank/drug/DB04894/identifier/kegg-drug/D06281 http://linked.opendata.cz/resource/drugbank/drug/DB04894/identifier/pubchem-compound/23725064 http://linked.opendata.cz/resource/drugbank/drug/DB04894/identifier/pubchem-substance/46506923 http://linked.opendata.cz/resource/drugbank/drug/DB04894/identifier/pharmgkb/PA164743146
http://linked.open...mechanismOfAction	The exact mechanism of action is unknown, although one study has provided in vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect in the analgesic effects of vapreotide (PMID: 7556407). (en)
http://linked.open...outeOfElimination	Vapreotide is 76% eliminated in bile. The remainder is renally eliminated. (en)
http://linked.open.../drugbank/synonym	Vapreotida (en) Vapreotidum (en)
http://linked.open...drugbank/toxicity	Safety data are limited, however, headache, fatigue, diarrhea, nausea, vomiting, and abdominal pain have been reported commonly with the use of vapreotide. (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Venkata Raghavendra Palle, Maheedhara Reddy Challa, "PROCESS FOR PREPARING VAPREOTIDE." U.S. Patent US20070111930, issued May 17, 2007. (en)
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	103222-11-3 (en)
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