About: Niflumic Acid     Goto   Sponge   Distinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. [PubChem] (en)
http://linked.open...generalReferences
  • # Criddle DN, de Moura RS, Greenwood IA, Large WA: Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol. 1997 Mar;120(5):813-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9138686 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 2.5 hours (en)
http://linked.open...ugbank/indication
  • Used in the treatment of rheumatoid arthritis. (en)
sameAs
Title
  • Niflumic Acid (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Niflumic acid is able to inhibit both phospholipase A2 as well as COX-2, thereby acting as an antiinflamatory and pain reduction agent. (en)
http://linked.open.../drugbank/synonym
  • Acide niflumique (en)
  • Acido niflumico (en)
  • Acidum niflumicum (en)
  • NFA (en)
  • Niflugel (en)
http://linked.open...drugbank/toxicity
  • Oral, mouse: LD<sub>50</sub> = 350 mg/kg; Oral, rat: LD<sub>50</sub> = 250 mg/kg (en)
http://linked.open...nk/proteinBinding
  • 90% bound to plasma proteins. (en)
http://linked.open...y/mesh/hasConcept
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Well absorbed following oral administration. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 4394-00-7 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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