About: Pantothenic acid

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description	Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient. Animals require pantothenic acid to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. Pantothenic acid is the amide between pantoic acid and β-alanine. Small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. It is commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate. Pantothenic acid is an ingredient in some hair and skin care products. Only the dextrorotatory (D) isomer of pantothenic acid possesses biologic activity. The levorotatory (L) form may antagonize the effects of the dextrorotatory isomer. [Wikipedia] (en)
http://linked.open...generalReferences	# Trumbo, P. R. (2006). "Pantothenic Acid". In Shils, M. E.; Shike, M.; Ross, A. C. et al.. Modern Nutrition in Health and Disease (10th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. pp. 462–467. ISBN 0-7817-4133-5. (en)
http://linked.open...gy/drugbank/group	nutraceutical (en)
http://linked.open...ugbank/indication	Studied for the treatment of many uses such as treatment of testicular torsion, diabetic ulceration, wound healing, acne, obesity, diabetic peripheral polyneuropathy. It has also been investigated for its hypolipidemic effects and as cholesterol lowering agent. (en)
sameAs	Pantothenic acid Pantothenic acid
Title	Pantothenic acid (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01783/identifier/drugbank/DB01783 http://linked.opendata.cz/resource/drugbank/drug/DB01783/identifier/pdb/PAU http://linked.opendata.cz/resource/drugbank/drug/DB01783/identifier/chebi/7916 http://linked.opendata.cz/resource/drugbank/drug/DB01783/identifier/kegg-compound/C00864 http://linked.opendata.cz/resource/drugbank/drug/DB01783/identifier/kegg-drug/D07413 http://linked.opendata.cz/resource/drugbank/drug/DB01783/identifier/wikipedia/Pantothenic_acid
http://linked.open...mechanismOfAction	Pantothenic acid is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE. (en)
http://linked.open.../drugbank/synonym	Vitamin B5 (en) (+)-Pantothenic acid (en) D-pantothenic acid (en) Pantothenate (en)
http://linked.open...drugbank/toxicity	No Tolerable Upper Level Intake (UL) has been established for the vitamin. (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	John F. Verbeeck, "Process for the production of the calcium salt of pantothenic acid." U.S. Patent US3935256, issued February, 1971. (en)
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http://linked.open...ugbank/absorption	When found in foods, most pantothenic acid is in the form of CoA or acyl carrier protein (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the lumen of the intestine, CoA and ACP are hydrolyzed into 4'-phosphopantetheine. The 4'-phosphopantetheine is then dephosphorylated into pantetheine. Pantetheinase, an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid. Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system. At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. As intake increases 10-fold, however, absorption rate decreases to 10%. [Wikipedia] (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	79-83-4 (en)
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