About: Pirbuterol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	The plasma half-life measured after oral administration is about two hours. (en)
http://linked.open...ugbank/indication	For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma. (en)
sameAs	Pirbuterol Pirbuterol
Title	Pirbuterol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01291/identifier/chemspider/4679 http://linked.opendata.cz/resource/drugbank/drug/DB01291/identifier/drugbank/DB01291 http://linked.opendata.cz/resource/drugbank/drug/DB01291/identifier/kegg-compound/C07807 http://linked.opendata.cz/resource/drugbank/drug/DB01291/identifier/national-drug-code-directory/0089-0815-21 http://linked.opendata.cz/resource/drugbank/drug/DB01291/identifier/pharmgkb/PA450983 http://linked.opendata.cz/resource/drugbank/drug/DB01291/identifier/pubchem-compound/4845 http://linked.opendata.cz/resource/drugbank/drug/DB01291/identifier/pubchem-substance/46506379
http://linked.open...mechanismOfAction	The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. (en)
http://linked.open...drugbank/packager	3M Health Care Graceway Pharmaceuticals Pharmedix Physicians Total Care Inc.
http://linked.open.../drugbank/synonym	Pirbuterol (en) Maxair autohaler (en) Pirbuterolum (en)
http://linked.open...drugbank/toxicity	As with all sympathomimetic aerosol medication, cardiac arrest and even death may be associated with abuse of pirbuterol. (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Berkeley W. Cue, Stephen S. Massett, "Intermediates for preparing pirbuterol and analogs." U.S. Patent US4632992, issued June, 1977. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0053542
foaf:page	http://www.drugs.com/cdi/pirbuterol.html http://www.rxlist.com/cgi/generic/pirbu.htm
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http://linked.open...l/drug/hasATCCode	Pirbuterol Pirbuterol
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	38677-81-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Maxair autohaler 0.2 mg aero Maxair Autohaler 200 mcg/inh Aerosol 14 gm Inhaler
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