About: Mitiglinide     Goto   Sponge   Distinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Mitiglinide is a drug for the treatment of type 2 diabetes .Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells. (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...ugbank/indication
  • For the treatment of type 2 diabetes. (en)
sameAs
Title
  • Mitiglinide (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Mitiglinide is thought to stimulate insulin secretion by binding to and blocking ATP-sensitive K(+) (K(ATP)) channels (Kir6.2/SUR1 complex, KATP channels) in pancreatic beta-cells. Closure of potassium channels causes depolarization which stimulates calcium influx through voltage-gated calcium channels. High intracellular calcium subsequently triggers the exocytosis of insulin granules. (en)
http://linked.open.../drugbank/synonym
  • KAD-1229 (en)
  • Mitiglinide calcium hydrate (en)
http://linked.open...y/mesh/hasConcept
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
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http://linked.open...bank/Refractivity
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http://linked.open...casRegistryNumber
  • 145375-43-5 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
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http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
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http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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