About: Chlormezanone

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. [PubChem] (en)
http://linked.open...generalReferences	# Wollina U, Hipler UC, Seeling A, Oelschlager H: Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro. Skin Pharmacol Physiol. 2005 May-Jun;18(3):132-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15897685 # Seeling A, Oelschlager H, Rothley D: [Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone] Pharmazie. 2000 Apr;55(4):293-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10798243 # Oelschlager H, Klinger W, Rothley D, Seeling A, Bockhard H, Hofmann B, Machts H, Riederer H, Rackur H: [Cleavage and biotransformation of the central muscle relaxant chlormezanone] Pharmazie. 1998 Sep;53(9):620-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9770210 # Gautier V, Vincon G, Demotes-Mainard F, Albin H: [Pharmacokinetics of chlormezanone in healthy volunteers] Therapie. 1990 Jul-Aug;45(4):315-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2399514 (en)
http://linked.open...gy/drugbank/group	approved (en) withdrawn (en)
http://linked.open...ugbank/indication	Used in the management of anxiety and in the treatment of muscle spasm. (en)
sameAs	Chlormezanone Chlormezanone
Title	Chlormezanone (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01178/identifier/chebi/3619 http://linked.opendata.cz/resource/drugbank/drug/DB01178/identifier/chemspider/2616 http://linked.opendata.cz/resource/drugbank/drug/DB01178/identifier/drugbank/DB01178 http://linked.opendata.cz/resource/drugbank/drug/DB01178/identifier/kegg-drug/D00268 http://linked.opendata.cz/resource/drugbank/drug/DB01178/identifier/pharmgkb/PA448939 http://linked.opendata.cz/resource/drugbank/drug/DB01178/identifier/pubchem-compound/2717 http://linked.opendata.cz/resource/drugbank/drug/DB01178/identifier/pubchem-substance/46505352 http://linked.opendata.cz/resource/drugbank/drug/DB01178/identifier/wikipedia/Chlormezanone
http://linked.open...mechanismOfAction	Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. (en)
http://linked.open.../drugbank/synonym	Chlormezanone (en) Chlormethazanone (en) (+-)-Chlormezanone (en) (±)-chlormezanone (en) Chlormezanona (en) Chlormezanonum (en) Clormezanona (en) 2-(P-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide (en) 2-(P-Chlorphenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death. (en)
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	80-77-3 (en)
http://linked.open...drugbank/category	(en)
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