About: Procarbazine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4D89-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	10 minutes (en)
http://linked.open...ugbank/indication	For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease. (en)
sameAs	Procarbazine Procarbazine
Title	Procarbazine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01168/identifier/chemspider/4746 http://linked.opendata.cz/resource/drugbank/drug/DB01168/identifier/drugbank/DB01168 http://linked.opendata.cz/resource/drugbank/drug/DB01168/identifier/kegg-compound/C07402 http://linked.opendata.cz/resource/drugbank/drug/DB01168/identifier/kegg-drug/D00478 http://linked.opendata.cz/resource/drugbank/drug/DB01168/identifier/pharmgkb/PA451112 http://linked.opendata.cz/resource/drugbank/drug/DB01168/identifier/pubchem-compound/4915 http://linked.opendata.cz/resource/drugbank/drug/DB01168/identifier/pubchem-substance/46507706 http://linked.opendata.cz/resource/drugbank/drug/DB01168/identifier/wikipedia/Procarbazine
http://linked.open...mechanismOfAction	The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis. Studies have suggested that procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA. The absence of functional t-RNA could cause the cessation of protein synthesis and consequently DNA and RNA synthesis. In addition, procarbazine may directly damage DNA. Hydrogen peroxide, formed during the auto-oxidation of the drug, may attack protein sulfhydryl groups contained in residual protein which is tightly bound to DNA. (en)
http://linked.open...drugbank/packager	AAIPharma Inc. B&B Pharmaceuticals APP Pharmaceuticals A-S Medication Solutions LLC
http://linked.open.../drugbank/synonym	Procarbazin (en) 1-Methyl-2-(P-(isopropylcarbamoyl)benzyl)hydrazine (en) 2-(P-Isopropylcarbamoylbenzyl)-1-methylhydrazine (en) 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide (en) N-4-Isopropylcarbamoylbenzyl-n'-methylhydrazine (en) N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide (en) N-Isopropyl-P-(2-methylhydrazinomethyl)-benzamide (en) N-Isopropyl-alpha-(2-methylhydrazino)-P-toluamide (en) P-(2-Methylhydrazinomethyl)-N-isopropylbenzamide (en) Procarbazina (en) Procarbazinum (en) N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub>=785 mg/kg (orally in rats) (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/10-00-00
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	"DrugSyn.org":http://www.drugsyn.org/Procarbazine.htm (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0017616
foaf:page	http://www.drugs.com/cdi/procarbazine.html http://www.rxlist.com/cgi/generic3/procarb.htm
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http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B4D94-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4D93-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4D90-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4D91-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B4D92-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Procarbazine
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4D9A-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4D9B-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B4D95-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B4D96-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B4D98-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B4D97-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B4D99-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Procarbazine is rapidly and completely absorbed. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	671-16-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Matulane 50 mg capsule
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B4DA0-363D-11E5-9242-09173F13E4C5
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http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B4DA1-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4D8F-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B4D9C-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B4D9D-363D-11E5-9242-09173F13E4C5

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