About: Doxacurium chloride     Goto   Sponge   Distinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. (en)
http://linked.open...generalReferences
  • # Martinez EA, Wooldridge AA, Hartsfield SM, Mealey KL: Neuromuscular effects of doxacurium chloride in isoflurane-anesthetized dogs. Vet Surg. 1998 May-Jun;27(3):279-83. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9605239 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 99 minutes in normal healthy adults. (en)
http://linked.open...ugbank/indication
  • Used to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation. (en)
sameAs
Title
  • Doxacurium chloride (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Doxacurium chloride binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission (non-depolarizing). This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine. (en)
http://linked.open...outeOfElimination
  • In vivo data from humans suggest that NUROMAX is not metabolized and that the major elimination pathway is excretion of unchanged drug in urine and bile. (en)
http://linked.open.../drugbank/synonym
  • Doxacurium (en)
http://linked.open...drugbank/toxicity
  • Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia. (en)
http://linked.open...umeOfDistribution
  • * 0.11-0.43 L/kg [Healthy Young Adult Patients] * 0.17-0.55 L/kg [Kidney Transplant Patients] * 0.17-0.35 L/kg [Liver Transplant Patients] (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...nk/proteinBinding
  • Approximately 30%. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 106819-53-8 (en)
http://linked.open...rugbank/clearance
  • * 2.66 mL/min/kg [Healthy Young Adult Patients] * 1.23 mL/min/kg [Kidney Transplant Patients] * 2.3 mL/min/kg [Liver Transplant Patients] * 1.75 +/- 0.16 mL/min/kg [Elderly patients (70-83 yrs)] * 2.54 +/- 0.24 mL/min/kg [younger patients (19-39 yrs)] (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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