About: Amlexanox

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population. (en)
http://linked.open...generalReferences	# Bell J: Amlexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig. 2005;25(9):555-66. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17532700 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	Elimination half-life is 3.5 ± 1.1 hours. (en)
http://linked.open...ugbank/indication	Used as a paste in the mouth to treat aphthous ulcers (canker sores). (en)
sameAs	Amlexanox Amlexanox
Title	Amlexanox (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/chebi/31205 http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/chemspider/2076 http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/drugbank/DB01025 http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/kegg-drug/D01828 http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/pubchem-compound/2161 http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/pubchem-substance/46504508 http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/pharmgkb/PA164745310
http://linked.open...mechanismOfAction	As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3. When cells are under stress, they release an inactive form of human fibroblast growth factor 1 (FGF-1), a potent mitogen (entity that causes mitosis). Amlexanox binds to FGF1, increasing its conformational stability, sterically blocking Cu(2+) induced oxidation which normally leads to activation of FGF-1. (en)
http://linked.open...drugbank/packager	A-S Medication Solutions LLC Bayer Healthcare Block Drug Corp. Contract Pharm
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5362737
http://linked.open.../drugbank/synonym	Amlexanox (en) Amoxanox (en) Amlexanoxo (en) Amlexanoxum (en) 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0132876
foaf:page	http://www.drugs.com/cdi/amlexanox.html
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B556C-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Amlexanox Amlexanox
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http://linked.open...ugbank/absorption	No significant absorption directly through the active ulcer. Most of the systemic absorption is via the gastrointestinal tract. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	68302-57-8 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Aphthasol 5% paste Aphthasol 5% Paste 3 gm Tube
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B5579-363D-11E5-9242-09173F13E4C5
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