About: Edetic Acid

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B46F0-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	The half life of edetate calcium disodium is 20 to 60 minutes. (en)
http://linked.open...ugbank/indication	For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults. (en)
http://linked.open...bank/manufacturer	App pharmaceuticals llc 3m pharmaceuticals inc Altana inc
sameAs	Edetic Acid Edetic Acid
Title	Edetic Acid (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/chemspider/5826 http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/drugbank/DB00974 http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/kegg-drug/D00571 http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/national-drug-code-directory/0089-0510-06 http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/pdb/EDT http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/pubchem-compound/6049 http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/pubchem-substance/46508301 http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/pharmgkb/PA449439 http://linked.opendata.cz/resource/drugbank/drug/DB00974/identifier/wikipedia/EDTA
http://linked.open...mechanismOfAction	The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased. (en)
http://linked.open...drugbank/packager	App pharmaceuticals llc Graceway Pharmaceuticals Hospira Inc. Merit Pharmaceuticals North America Genescience LLC Sanofi-Aventis Inc. Torrance Co. Baxter healthcare corp anesthesia and critical care
http://linked.open...outeOfElimination	It is excreted primarily by the kidney, with about 50% excreted in one hour and over 95% within 24 hours.2 Almost none of the compound is metabolized. (en)
http://linked.open.../drugbank/synonym	EDTA (en) 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate (en) (Ethylenedinitrilo)tetraacetic acid, ion(4-) (en) Acide edetique (en) Acide ethylenediaminetetracetique (en) Acido edetico (en) Acidum edeticum (en) EDTA, ion(4-) (en) Edetic acid (en) Ethylenediaminetetraacetate (en) Ethylenediaminetetraacetic acid (en) H4Edta (en) N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine) (en) {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid (en)
http://linked.open...drugbank/toxicity	Inadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency. (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Bersworth, F.C.; U.S. Patent 2,407,645; September 17,1946; assigned to The Martin Dennis Co. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0007067
foaf:page	http://www.rxlist.com/cgi/generic2/canaversenate.htm
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B46FA-363D-11E5-9242-09173F13E4C5
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http://linked.open...ugbank/absorption	Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	62-33-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Danazol 200 mg capsule
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B4707-363D-11E5-9242-09173F13E4C5
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http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B4703-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B4704-363D-11E5-9242-09173F13E4C5

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