About: Colesevelam

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B635E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B635F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B6360-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B6361-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For use, alone or in combination with an HMG-CoA reductase inhibitor, as adjunctive therapy to diet and exercise for the reduction of elevated LDL cholesterol in patients with primary hypercholesterolemia (Fredrickson Type IIa). (en)
http://linked.open...bank/manufacturer	Baxter International Inc.
sameAs	Colesevelam Colesevelam
Title	Colesevelam (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00930/identifier/chemspider/140701 http://linked.opendata.cz/resource/drugbank/drug/DB00930/identifier/drugbank/DB00930 http://linked.opendata.cz/resource/drugbank/drug/DB00930/identifier/national-drug-code-directory/65597-701-18 http://linked.opendata.cz/resource/drugbank/drug/DB00930/identifier/pharmgkb/PA449095 http://linked.opendata.cz/resource/drugbank/drug/DB00930/identifier/wikipedia/Colesevelam
http://linked.open...mechanismOfAction	Colesevelam is a non-absorbed, lipid-lowering polymer that binds bile acids in the intestine, impeding their reabsorption. As the bile acid pool becomes depleted, the hepatic enzyme, cholesterol 7-(alpha)-hydroxylase, is upregulated, which increases the conversion of cholesterol to bile acids. This causes an increased demand for cholesterol in the liver cells, resulting in the dual effect of increasing transcription and activity of the cholesterol biosynthetic enzyme, hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase, and increasing the number of hepatic low-density lipoprotein (LDL) receptors. These compensatory effects result in increased clearance of LDL cholesterol (LDL-C) from the blood, resulting in decreased serum LDL-C levels. Serum triglyceride levels may increase or remain unchanged. The end result is increased clearance of LDL-cholesterol from the blood with decreased serum LDL-cholesterol. (en)
http://linked.open...drugbank/packager	Daiichi Sankyo Patheon Inc. Aurobindo pharma ltd Ivax pharmaceuticals inc Lupin ltd Roxane laboratories inc
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5679717 http://linked.opendata.cz/resource/drugbank/patent/7229613
http://linked.open...outeOfElimination	Excretion: In 16 healthy volunteers, an average of 0.05% of administered radioactivity from a single 14C-labeled colesevelam hydrochloride dose was excreted in the urine. (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose may include eye irritation, constipation, abdominal cramps, nausea, vomiting, diarrhea, and hypersensitivity. However, as colesevelam is not absorbed, the risk of systemic toxicity is low. Doses in excess of 4.5 g per day have not been tested. (en)
http://linked.open...k/foodInteraction	Drink liberally. (en) Take with a meal. (en)
http://linked.open...nk/proteinBinding	Not applicable (not hydrolyzed by digestive enzymes and not absorbed). (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0278679
foaf:page	http://www.drugs.com/cdi/colesevelam.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/wel1551.shtml http://www.rxlist.com/cgi/generic2/colesevelam.htm
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B6362-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Colesevelam
http://linked.open...ugbank/absorption	Not hydrolyzed by digestive enzymes and is not absorbed. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	182815-44-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Perindopril erbumine 2 mg tablet

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