| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. [PubChem] (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...generalReferences
| - # McBain AJ, Bartolo RG, Catrenich CE, Charbonneau D, Ledder RG, Gilbert P: Effects of a chlorhexidine gluconate-containing mouthwash on the vitality and antimicrobial susceptibility of in vitro oral bacterial ecosystems. Appl Environ Microbiol. 2003 Aug;69(8):4770-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12902270 (en)
|
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...ugbank/indication
| - For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in health-care personnel, general skin cleanser, and catheter site preparation and care. (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open...y/drugbank/patent
| |
| http://linked.open...outeOfElimination
| - Excretion of chlorhexidine gluconate occurred primarily through the feces (~90%). Less than 1% of the chlorhexidine gluconate ingested by these subjects was excreted in the urine. (en)
|
| http://linked.open.../drugbank/synonym
| - Chlorhexidine (en)
- Chlorhexidin (en)
- Chlorhexidinum (en)
- Cloresidina (en)
- Clorhexidina (en)
- N,N'-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (en)
- 1,1'-Hexamethylene bis(5-(P-chlorophenyl)biguanide) (en)
|
| http://linked.open...drugbank/toxicity
| - LD<sub>50</sub>= 2g/kg (human, oral); LD<sub>50</sub>= 3 g/kg (rat, oral); LD<sub>50</sub>= 2.5 g/kg (mice, oral); LD<sub>50</sub>= 21 mg/kg (male rat, IV); LD<sub>50</sub>= 23 mg/kg (female rat, IV); LD<sub>50</sub>= 25 mg/kg (male mice, IV); LD<sub>50</sub>= 24 mg/kg (female mice, IV); LD<sub>50</sub>= 1g/kg (rat, subcutaneous); LD<sub>50</sub>= 637 mg/kg (male mice, subcutaneous); LD<sub>50</sub>= 632 mg/kg (female mice, subcutaneous) (en)
|
| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open.../drugbank/mixture
| |
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