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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Benzonatate is a non-narcotic oral antitussive (cough suppressant) drug which works by anesthetizing the tissues of the lungs and pleura responsible for the cough reflex. It is chemically related to other ester anesthetics such as procaine. It has an anesthetic (numbing) action similar to that of benzocaine and "numbs" the stretch sensors in the lungs. It is the stretching of these sensors with breathing that causes the cough. It was approved by the FDA in 1958. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Cohen V, Jellinek SP, Stansfield L, Truong H, Baseluos C, Marshall JP: Cardiac arrest with residual blindness after overdose of tessalon(R) (benzonatate) perles. J Emerg Med. 2009 Nov 4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19892505 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 3-8 hours (en)
http://linked.open...ugbank/indication
  • For the symptomatic relief of cough. Has also been applied locally in the oral cavity in adults by releasing the drug from the liquid-filled capsules to provide oropharyngeal anesthesia for conscious intubation. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Benzonatate (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. Since these receptors are responsible for mediating the cough reflex, anesthetizing these receptors result in the inhibiton of cough production. Benzonatate also suppresses transmission of the cough reflex at the level of the medulla where the afferent impulse is transmitted to the motor nerves. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Benzonatate (en)
  • Benzononatine (en)
  • Benzonatat (en)
  • Benzonatato (en)
  • Benzonatatum (en)
  • 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl P-(butylamino)benzoate (en)
  • Nonaethyleneglycol monomethyl ether P-N-butylaminobenzoate (en)
  • 2-[2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoate (en)
  • 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosyl 4-butylaminobenzoate (en)
  • 4-(Butylamino)benzoic acid 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester (en)
  • P-Butylaminobenzoic acid omega-O-methylnonaethyleneglycol ester (en)
http://linked.open...drugbank/toxicity
  • Restlessness, tremors, seizures and unconsciousness. (en)
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