About: Propofol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4368-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Vasile B, Rasulo F, Candiani A, Latronico N: The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med. 2003 Sep;29(9):1417-25. Epub 2003 Aug 6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12904852 # Ke JJ, Zhan J, Feng XB, Wu Y, Rao Y, Wang YL: A comparison of the effect of total intravenous anaesthesia with propofol and remifentanil and inhalational anaesthesia with isoflurane on the release of pro- and anti-inflammatory cytokines in patients undergoing open cholecystectomy. Anaesth Intensive Care. 2008 Jan;36(1):74-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18326136 # Hong JY, Kang YS, Kil HK: Anaesthesia for day case excisional breast biopsy: propofol-remifentanil compared with sevoflurane-nitrous oxide. Eur J Anaesthesiol. 2008 Feb 26;:1-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18298873 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	Initial distribution phase t<sub>1/2α</sub>=1.8-9.5 minutes. Second redistirubtion phase t<sub>1/2β</sub>=21-70 minutes. Terminal elimination phase t<sub>1/2γ</sub>=1.5-31 hours. (en)
http://linked.open...ugbank/indication	Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus. (en)
http://linked.open...bank/manufacturer	Abic ltd Abraxis pharmaceutical products App pharmaceuticals llc PD-Rx Pharmaceuticals Inc.
sameAs	Propofol Propofol
Title	Propofol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/chebi/8495 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/chemspider/4774 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/drugbank/DB00818 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/kegg-compound/C07523 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/kegg-drug/D00549 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/national-drug-code-directory/0409-4699-30 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/pdb/PFL http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/pharmgkb/PA451141 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/pubchem-compound/4943 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/pubchem-substance/46504991 http://linked.opendata.cz/resource/drugbank/drug/DB00818/identifier/wikipedia/Propofol
http://linked.open...mechanismOfAction	The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid (GABA) through GABA-A receptors. (en)
http://linked.open...drugbank/packager	AstraZeneca Inc. Baxter International Inc. APP Pharmaceuticals Cardinal Health Atlantic Biologicals Corporation Pfizer Inc. Cardinal Health Contract Pharm
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2212794 http://linked.opendata.cz/resource/drugbank/patent/5714520
http://linked.open...outeOfElimination	It is chiefly eliminated by hepatic conjugation to inactive metabolites which are excreted by the kidney. (en)
http://linked.open.../drugbank/synonym	Propofol (en) Diprivan (en) Disoprivan (en) Disoprofol (en) Rapinovet (en) 2,6-Diisopropylphenol (en) 2,6-Bis(1-methylethyl)phenol (en) Propofolum (en)
http://linked.open...drugbank/toxicity	Overdosage may increase pharmacologic and adverse effects or cause death. <p>IV LD<sub>50</sub>=53 mg/kg (mice), 42 mg/kg (rats). Oral LD<sub>50</sub> (as a solution in soybean oil)=1230 mg/kg (mice), 600 mg/kg (rats)</p> (en)
http://linked.open...umeOfDistribution	* 60 L/kg [healthy adults] (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/28-04-92
http://linked.open...nk/proteinBinding	95 to 99%, primarily to serum albumin and hemoglobin (en)
http://linked.open...ynthesisReference	John R. Carpenter, "Propofol-based anesthetic and method of making same." U.S. Patent US6150423, issued May, 1977. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0024130
foaf:page	http://www.drugs.com/propofol.html http://www.rxlist.com/cgi/generic2/propof.htm
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http://linked.open...ugbank/absorption	Rapid - time to onset of unconsciousness is 15-30 seconds, due to rapid distribution from plasma to the CNS. Distribution is so rapid that peak plasma concentrations cannot be readily measured. Duration of action is 5-10 minutes. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	2078-54-8 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 23 - 50 mL/kg/min * 1.6 - 3.4 L/min [70 Kg adults] (en)
http://linked.open...gbank/containedIn	Propoven 500 mg/50 ml vial Eurax 10% Cream 60 gm Tube Eurax 10% Lotion 60 gm Bottle Eurax 10% Lotion 454 gm Bottle Eurax 10% cream Diprivan 10 mg/ml vial
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