About: Gentamicin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1a, obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (genetic translation). [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B6554-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B6555-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B6556-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B6557-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B6558-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B6559-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B655A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B655B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B655C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B655D-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	3-3½ hours in infants one week to six months of age; this increases to 5½ hours in full-term and large premature infants less than one week old. (en)
http://linked.open...ugbank/indication	For treatment of serious infections caused by susceptible strains of the following microorganisms: <i>P. aeruginosa</i>, <i>Proteus</i> species (indole-positive and indole-negative), <i>E. coli</i>, <i>Klebsiella-Enterobactor-Serratia</i> species, <i>Citrobacter</i> species and <i>Staphylococcus</i> species (coagulase-positive and coagulase-negative). (en)
http://linked.open...bank/manufacturer	Major Pharmaceuticals Actavis totowa llc Alpharma us pharmaceuticals division Amerisource Health Services Corp. Apotex inc Aurobindo pharma ltd Caraco pharmaceutical laboratories ltd Dr reddys laboratories ltd Gedeon richter usa inc Pfizer Inc. Contract Pharm Abbott laboratories pharmaceutical products div Ivax pharmaceuticals inc sub teva pharmaceuticals usa Baxter healthcare corp anesthesia and critical care Hospira inc Mutual pharmacal co Mylan laboratories inc Orchid healthcare Ranbaxy laboratories ltd Roxane laboratories inc Teva pharmaceuticals usa inc B braun medical inc Actavis totowa llc Advanced Pharmaceutical Services Inc. AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Altana inc Allergan Pfizer Inc. Dr reddys laboratories inc Pharmaceutical Utilization Management Program VA Inc.
sameAs	Gentamicin Gentamicin
Title	Gentamicin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/chebi/17833 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/chemspider/3348 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/drugbank/DB00798 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/guide-to-pharmacology/2427 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/iuphar/2427 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/kegg-compound/C00505 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/national-drug-code-directory/17478-283-10 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/pharmgkb/PA449753 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/pubchem-compound/3467 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/pubchem-substance/46506523 http://linked.opendata.cz/resource/drugbank/drug/DB00798/identifier/wikipedia/Gentamicin
http://linked.open...mechanismOfAction	Aminoglycosides like gentamicin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically gentamicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. (en)
http://linked.open...drugbank/packager	Accutome Inc. Advanced Pharmaceutical Services Inc. Akorn Inc. Alcon Laboratories APP Pharmaceuticals A-S Medication Solutions LLC B. Braun Melsungen AG Bausch & Lomb Inc. Baxter International Inc. Cardinal Health Carlisle Laboratories Inc. Darby Dental Supply Co. Inc. Dispensing Solutions Diversified Healthcare Services Inc. E. Fougera and Co. Falcon Pharmaceuticals Ltd. Pfizer Inc. Pharmaceutical Utilization Management Program VA Inc. Hospira Inc. Innoviant Pharmacy Inc. Keltman Pharmaceuticals Inc. Major Pharmaceuticals Martin Surgical Supply Medisca Inc. MWI Veterinary Supply Co. Novartis AG Nycomed Inc. Ocusoft OMJ Pharmaceuticals Pacific Pharma Lp Actavis Group A-S Medication Solutions LLC C.O. Truxton Inc. Direct Dispensing Inc. Dispensing Solutions Diversified Healthcare Services Inc. G & W Labs Rebel Distributors Corp. H.J. Harkins Co. Inc.

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