About: Reboxetine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description	Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. (en)
http://linked.open...generalReferences	# Fleishaker JC: Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression. Clin Pharmacokinet. 2000 Dec;39(6):413-27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11192474 # Edwards DM, Pellizzoni C, Breuel HP, Berardi A, Castelli MG, Frigerio E, Poggesi I, Rocchetti M, Dubini A, Strolin Benedetti M: Pharmacokinetics of reboxetine in healthy volunteers. Single oral doses, linearity and plasma protein binding. Biopharm Drug Dispos. 1995 Aug;16(6):443-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7579027 # Wienkers LC, Allievi C, Hauer MJ, Wynalda MA: Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes. Drug Metab Dispos. 1999 Nov;27(11):1334-40. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10534319 # Kasper S, el Giamal N, Hilger E: Reboxetine: the first selective noradrenaline re-uptake inhibitor. Expert Opin Pharmacother. 2000 May;1(4):771-82. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11249515 # Fleishaker JC: Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression. Clin Pharmacokinet. 2000 Dec;39(6):413-27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11192474 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	12.5 hours (en)
http://linked.open...ugbank/indication	For the treatment of clinical depression. (en)
sameAs	Reboxetine Reboxetine
Title	Reboxetine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00234/identifier/bindingdb/35226 http://linked.opendata.cz/resource/drugbank/drug/DB00234/identifier/chemspider/59268 http://linked.opendata.cz/resource/drugbank/drug/DB00234/identifier/drugbank/DB00234 http://linked.opendata.cz/resource/drugbank/drug/DB00234/identifier/pubchem-compound/65856 http://linked.opendata.cz/resource/drugbank/drug/DB00234/identifier/pubchem-substance/46504845 http://linked.opendata.cz/resource/drugbank/drug/DB00234/identifier/pharmgkb/PA144614921 http://linked.opendata.cz/resource/drugbank/drug/DB00234/identifier/wikipedia/Reboxetine
http://linked.open...mechanismOfAction	Reboxetine is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake <i>in vitro</i> to a similar extent to the tricyclic antidepressant desmethylimipramine. Reboxetine does not affect dopamine or serotonin reuptake and it has low <i>in vivo</i> and <i>in vitro</i> affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors. (en)
http://linked.open.../drugbank/synonym	Reboxetine (en) (S (en) Esreboxetine (en) S)-Reboxetine (en) SID11114256 (en)
http://linked.open...drugbank/toxicity	Reports of seizures (rare) have been reported (en)
http://linked.open...nk/proteinBinding	98% (en)
http://linked.open...ogy/drugbank/salt	(en)
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http://linked.open...ugbank/absorption	Reboxetine is rapidly and extensively absorbed following oral administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	98769-81-4 (en)
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