About: Gadodiamide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Gadodiamide is a gadolinium based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. It is commonly marketed under the trade name Omniscan. [Wikipedia] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B6020-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Two-compartment model with mean distribution and elimination half-lives (reported as mean ± SD) of 3.7 ± 2.7 minutes and 77.8 ± 16 minutes, respectively. (en)
http://linked.open...ugbank/indication	For intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues. (en)
http://linked.open...bank/manufacturer	Ge healthcare
sameAs	Gadodiamide Gadodiamide
Title	Gadodiamide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/chemspider/54756 http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/drugbank/DB00225 http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/kegg-compound/C13106 http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/kegg-drug/D01645 http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/national-drug-code-directory/0407-0690-05 http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/pubchem-compound/60754 http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/pubchem-substance/46504789 http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/pharmgkb/PA164784027 http://linked.opendata.cz/resource/drugbank/drug/DB00225/identifier/wikipedia/Gadodiamide
http://linked.open...mechanismOfAction	Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. Paramagnetic agents have unpaired electrons that generate a magnetic field about 700 times larger than the proton's field, thus disturbing the proton's local magnetic field. When the local magnetic field around a proton is disturbed, its relaxation process is altered. MR images are based on proton density and proton relaxation dynamics. MR instruments can record 2 different relaxation processes, the T1 (spin-lattice or longitudinal relaxation time) and the T2 (spin-spin or transverse relaxation time). In magnetic resonance imaging (MRI), visualization of normal and pathological brain tissue depends in part on variations in the radiofrequency signal intensity that occur with changes in proton density, alteration of the T1, and variation in the T2. When placed in a magnetic field, gadodiamide shortens both the T1 and the T2 relaxation times in tissues where it accumulates. At clinical doses, gadodiamide primarily affects the T1 relaxation time, thus producing an increase in signal intensity. Gadodiamide does not cross the intact blood-brain barrier; therefore, it does not accumulate in normal brain tissue or in central nervous system (CNS) lesions that have not caused an abnormal blood-brain barrier (e.g., cysts, mature post-operative scars). Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadodiamide in lesions such as neoplasms, abscesses, and subacute infarcts. (en)
http://linked.open...drugbank/packager	Paddock laboratories inc GE Healthcare Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1335819 http://linked.opendata.cz/resource/drugbank/patent/5362475 http://linked.opendata.cz/resource/drugbank/patent/5560903
http://linked.open...outeOfElimination	Gadodiamide is eliminated primarily in the urine. (en)
http://linked.open.../drugbank/synonym	Gadodiamide (en) Omniscan (en) Gadodiamide hydrate (en) Gadodiamida (en) Gadodiamidum (en) Gadolinium 5,8-bis(carboxylatomethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oate hydrate (en) Gadolinium [bis(2-{(carboxylatomethyl)[2-(methylamino)-2-oxoethyl]amino}ethyl)amino]acetate--water (1/1) (en)
http://linked.open...umeOfDistribution	* 200 ± 61 mL/kg (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-00-00
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0178725
foaf:page	http://www.rxlist.com/cgi/generic3/omniscan.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B6022-363D-11E5-9242-09173F13E4C5
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B6027-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Gadodiamide
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http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B602B-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B602D-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	122795-43-1 (en)
http://linked.open...rugbank/clearance	* Renal cl=1.7 mL/min/kg * Plasma cl=1.8 mL/min/kg (en)
http://linked.open...gbank/containedIn	Clozaril 100 mg tablet Clozapine 200 mg tablet Fazaclo 100 mg odt
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B6034-363D-11E5-9242-09173F13E4C5
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http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B6031-363D-11E5-9242-09173F13E4C5

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