About: Tenecteplase

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Tissue plasminogen activator (tPA). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B409A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B409B-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Gurbel PA, Hayes K, Bliden KP, Yoho J, Tantry US: The platelet-related effects of tenecteplase versus alteplase versus reteplase. Blood Coagul Fibrinolysis. 2005 Jan;16(1):1-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15650539 # Melzer C, Richter C, Rogalla P, Borges AC, Theres H, Baumann G, Laule M: Tenecteplase for the treatment of massive and submassive pulmonary embolism. J Thromb Thrombolysis. 2004 Aug;18(1):47-50. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15744554 # Ohman EM, Van de Werf F, Antman EM, Califf RM, de Lemos JA, Gibson CM, Oliverio RL, Harrelson L, McCabe C, DiBattiste P, Braunwald E: Tenecteplase and tirofiban in ST-segment elevation acute myocardial infarction: results of a randomized trial. Am Heart J. 2005 Jul;150(1):79-88. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16084152 # De Luca G, Suryapranata H, Chiariello M: Tenecteplase followed by immediate angioplasty is more effective than tenecteplase alone for people with STEMI. Commentary. Evid Based Cardiovasc Med. 2005 Dec;9(4):284-7. Epub 2005 Nov 2. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16380055 # : Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction (ASSENT-4 PCI): randomised trial. Lancet. 2006 Feb 18;367(9510):569-78. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16488800 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	1.9 hours (mammalian reticulocytes, in vitro) >20 hours (yeast, in vivo) >10 hours (Escherichia coli, in vivo) (en)
http://linked.open...ugbank/indication	For treatment of myocardial infarction and lysis of intracoronary emboli (en)
sameAs	Tenecteplase Tenecteplase
Title	Tenecteplase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00031/identifier/drugbank/DB00031 http://linked.opendata.cz/resource/drugbank/drug/DB00031/identifier/genbank/L00153 http://linked.opendata.cz/resource/drugbank/drug/DB00031/identifier/kegg-drug/D06070 http://linked.opendata.cz/resource/drugbank/drug/DB00031/identifier/national-drug-code-directory/50242-038-61 http://linked.opendata.cz/resource/drugbank/drug/DB00031/identifier/uniprotkb/P00750 http://linked.opendata.cz/resource/drugbank/drug/DB00031/identifier/pharmgkb/PA164776757 http://linked.opendata.cz/resource/drugbank/drug/DB00031/identifier/wikipedia/Tenecteplase
http://linked.open...mechanismOfAction	Tenecteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. (en)
http://linked.open...drugbank/packager	Comprehensive Consultant Services Inc. Dept Health Central Pharmacy
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1341432 http://linked.opendata.cz/resource/drugbank/patent/2129660
http://linked.open.../drugbank/synonym	Tissue-type plasminogen activator precursor (en) t- PA (en) t-plasminogen activator (en) tPA (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/20-12-20
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0335155
foaf:page	http://www.drugs.com/mtm/tenecteplase.html http://www.rxlist.com/cgi/generic2/tenecteplase.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B40A0-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B409F-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Tenecteplase
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	191588-94-0 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 99 - 119 mL/min [acute myocardial infarction patients] (en)
http://linked.open...gbank/containedIn	Kionex Powder
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B409D-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B409E-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B409C-363D-11E5-9242-09173F13E4C5

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