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rdf:type
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Description
| - 3-Thiocyanatoquinolone-2,4-diones 2, accessible by thiocyanation of 4-hydroxy-2-quinolones, are highly sensitive towards water. However, their conversion to compounds 3 and 4 can be carried out in 96% sulfuric acid. In the presence of excess of phosphorus pentoxide, C-dealkylated compound 5 (R1 =H) was obtained from 2 (R1 = H, R2 = Bu). Inasmuch as compounds 4 can be smoothly converted to valuable compounds 7 and 8 and compounds 5 are hardly obtainable from 3-unsubstituted 2-quinolones, we decided to study the reaction of compounds 2 in detail. The influence of the type of substitution at positions 1 and 4 in 2, composition of the reaction mixture and its processing, and the reaction time on the yield of individual products 3-5 and also on lately isolated compounds 6 was studied. The results will be discussed and the reaction mechanism will be proposed.
- 3-Thiocyanatoquinolone-2,4-diones 2, accessible by thiocyanation of 4-hydroxy-2-quinolones, are highly sensitive towards water. However, their conversion to compounds 3 and 4 can be carried out in 96% sulfuric acid. In the presence of excess of phosphorus pentoxide, C-dealkylated compound 5 (R1 =H) was obtained from 2 (R1 = H, R2 = Bu). Inasmuch as compounds 4 can be smoothly converted to valuable compounds 7 and 8 and compounds 5 are hardly obtainable from 3-unsubstituted 2-quinolones, we decided to study the reaction of compounds 2 in detail. The influence of the type of substitution at positions 1 and 4 in 2, composition of the reaction mixture and its processing, and the reaction time on the yield of individual products 3-5 and also on lately isolated compounds 6 was studied. The results will be discussed and the reaction mechanism will be proposed. (en)
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Title
| - Transformation of 3-Thiocyanatoquinoline-2,4-diones in a Strong Acidic Medium
- Transformation of 3-Thiocyanatoquinoline-2,4-diones in a Strong Acidic Medium (en)
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skos:prefLabel
| - Transformation of 3-Thiocyanatoquinoline-2,4-diones in a Strong Acidic Medium
- Transformation of 3-Thiocyanatoquinoline-2,4-diones in a Strong Acidic Medium (en)
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skos:notation
| - RIV/70883521:28110/11:43867499!RIV12-MSM-28110___
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/70883521:28110/11:43867499
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - thiocyanates, quinolones, dealkylation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Lyčka, Antonín
- Klásek, Antonín
- Rudolf, Ondřej
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http://localhost/t...ganizacniJednotka
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