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  • Hydrophobic substances (phthalocy anines) tend to aggregate in hydrophilic environment (bloodstream) and as a result they can lose their unique properties (photosensitivity). This can be overcome by encapsulating the substances into a drug delivery carrier, e.g. spheres from a biocompatible and biodegradable polymer. In thispaper polycaprolactone (PCL) spheres were synthetized by electrospraying, a method for preparation of polymeric micro- and nanospheres by high voltage application to a jet of polymer solution. The concentration dependence of PCL solution was investigated in the range of 1 % PCL solution to 10 % PCL solution. The samples were analyzed by scanning electron microscopy (SEM). The 7 % and 8 % PCL solutions seem to be the best concentration for PCL spheres preparation.
  • Hydrophobic substances (phthalocy anines) tend to aggregate in hydrophilic environment (bloodstream) and as a result they can lose their unique properties (photosensitivity). This can be overcome by encapsulating the substances into a drug delivery carrier, e.g. spheres from a biocompatible and biodegradable polymer. In thispaper polycaprolactone (PCL) spheres were synthetized by electrospraying, a method for preparation of polymeric micro- and nanospheres by high voltage application to a jet of polymer solution. The concentration dependence of PCL solution was investigated in the range of 1 % PCL solution to 10 % PCL solution. The samples were analyzed by scanning electron microscopy (SEM). The 7 % and 8 % PCL solutions seem to be the best concentration for PCL spheres preparation. (en)
Title
  • Synthesis of Polymeric Drug Carriers for Targeted Delivery of Bioactive Compounds
  • Synthesis of Polymeric Drug Carriers for Targeted Delivery of Bioactive Compounds (en)
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  • Synthesis of Polymeric Drug Carriers for Targeted Delivery of Bioactive Compounds
  • Synthesis of Polymeric Drug Carriers for Targeted Delivery of Bioactive Compounds (en)
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  • RIV/68407700:21460/12:00202770!RIV13-MSM-21460___
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  • P(EE.2.3.20.0092)
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  • 172984
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  • RIV/68407700:21460/12:00202770
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  • bloodstream; photosensitivity; , diseased cells; , lipophilic substances (en)
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  • [8A87D3EF66F4]
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  • Kladno
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  • Prague
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  • Instuments and Methods for Biology and Medicine 2012
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  • Jarošíková, Taťána
  • Buzgov, M.
  • Míčková, A.
  • Vocetková, Karolína
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  • České vysoké učení technické v Praze
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  • 978-80-01-05119-1
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  • 21460
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