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  • High-frequency cortical activity, particularly in the 250-600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis.
  • High-frequency cortical activity, particularly in the 250-600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. (en)
Title
  • Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
  • Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy (en)
skos:prefLabel
  • Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
  • Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy (en)
skos:notation
  • RIV/68407700:21230/10:00167945!RIV11-MSM-21230___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S, Z(MSM6840770012)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 257399
http://linked.open...ai/riv/idVysledku
  • RIV/68407700:21230/10:00167945
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • high-frequency activity; epilepsy; seizure onset; ripples; fast ripples; ictogenesis; temporal lobe epilepsy (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [E67F7A1F338D]
http://linked.open...i/riv/nazevZdroje
  • Brain
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 133
http://linked.open...iv/tvurceVysledku
  • Čmejla, Roman
  • Jiruska, P.
  • Finnerty, G. T.
  • Jefferys, G. R.
  • Lofti, N.
  • Powell, A. D.
http://linked.open...ain/vavai/riv/wos
  • 000277225700017
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-8950
number of pages
http://localhost/t...ganizacniJednotka
  • 21230
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