About: A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA.

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About: A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA. Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The intensity of the mixed hymphocyte response (MLR) depends on the genetic disparity between the donors of responding and stimulating cells. Differences in the major histocompatibility complex (MHC) and Mls1 antigens induce the strongest response. However, even with comparable incompatibilities in MHC and Mls antigens, some mouse strains respond remarkably better than other strains. In order to identify non-MHC genes influencing MLR, we analyzed the genetic differences in response to three different alloantigens C57BL-10 (H2 b ), BALB-c (H2 d ) and CBA (H2 k ) between the strains OcB-9 and O20 (both H2 pz ). We identified locus Alan2 on chromosome 4 that influences the response to all alloantigens tested. The intensity of the mixed hymphocyte response (MLR) depends on the genetic disparity between the donors of responding and stimulating cells. Differences in the major histocompatibility complex (MHC) and Mls1 antigens induce the strongest response. However, even with comparable incompatibilities in MHC and Mls antigens, some mouse strains respond remarkably better than other strains. In order to identify non-MHC genes influencing MLR, we analyzed the genetic differences in response to three different alloantigens C57BL-10 (H2 b ), BALB-c (H2 d ) and CBA (H2 k ) between the strains OcB-9 and O20 (both H2 pz ). We identified locus Alan2 on chromosome 4 that influences the response to all alloantigens tested. (en)
Title	A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA. A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA. (en)
skos:prefLabel	A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA. A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA. (en)
skos:notation	RIV/68378050:_____/00:23010247!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	483;487
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OK 394), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Lipoldová, Marie Havelková, Helena Badalová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	703614
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/00:23010247
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N/A (en)
http://linked.open.../riv/klicoveSlovo	N/A
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C276D04DDDA6]
http://linked.open...i/riv/nazevZdroje	Genes and Immunity
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OK%20394
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Demant, P. Havelková, Helena Lipoldová, Marie Badalová, Jana
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1466-4879
number of pages	5 (xsd:int)

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