About: The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have analyzed the relative effects of the stage of differentiation and the postischemic environment on the formation of adverse structures by transplanted differently mature human embryonic stem cell-derived neural progenitors (NPs). The influence of the postischemic environment was limited to graft survival and occurrence of nonneuroectodermal structures after transplantation of very immature NPs. Both effects were lost with differentiation. We identified a particular stage of differentiation characterized in vitro by a rebound of proliferative aktivity that produced highly proliferative grafts susceptible to threaten surrounding host tissues. The effects of the ischemic environment on the formation of teratoma by transplanted NPs are limited to early differentiation stages that will likely not be used for stem cell therapy. In contrast, hyperproliferation observed at later stages of differentiation corresponds to an intrinsic activity that should be monitored to avoid tumorigenesis in vivo. We have analyzed the relative effects of the stage of differentiation and the postischemic environment on the formation of adverse structures by transplanted differently mature human embryonic stem cell-derived neural progenitors (NPs). The influence of the postischemic environment was limited to graft survival and occurrence of nonneuroectodermal structures after transplantation of very immature NPs. Both effects were lost with differentiation. We identified a particular stage of differentiation characterized in vitro by a rebound of proliferative aktivity that produced highly proliferative grafts susceptible to threaten surrounding host tissues. The effects of the ischemic environment on the formation of teratoma by transplanted NPs are limited to early differentiation stages that will likely not be used for stem cell therapy. In contrast, hyperproliferation observed at later stages of differentiation corresponds to an intrinsic activity that should be monitored to avoid tumorigenesis in vivo. (en)
Title	The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors (en)
skos:prefLabel	The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors (en)
skos:notation	RIV/68378041:_____/10:00339447!RIV10-AV0-68378041
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Syková, Eva Kozubenko, Nataliya Jendelová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	280329
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/10:00339447
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	brain transplantation; human embryonic stem cells; neural differentiation (en)
http://linked.open.../riv/klicoveSlovo	brain transplantation neural differentiation human embryonic stem cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B679DDE48C7D]
http://linked.open...i/riv/nazevZdroje	Stroke
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	18 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Syková, Eva Jendelová, Pavla Brenot, M. Itier, V. Onteniente, B. Polentes, J. Seminatore, CH. Guidou, E. Kozubenko, Nataliya Aubry, L. Blondeau, J. Bugi, A. Ellman, D. Finsen, B. Lhuillier, M. Perrier, A. L. Tine, S. Tritschler, L.
http://linked.open...ain/vavai/riv/wos	000273093400026
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	0039-2499
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors

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