About: Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation

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About: Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pomocí počítačového modelování (restraint-based comparative modeling) byl vyvinut model H4-H5-smyčky α2-isoformy Na+/K+-ATPázy z myšího mozku. Vodíková vazba mezi atomem kyslíku Asp369 a atomem dusíku a Lys690 je klíčovým faktoren nezbytným pro strukturu fosforylačního místa v E1 konformaci. (cs) Restraint-based comparative modeling was used for calculation and visualization of the H4-H5-loop of α2-isoform of Na+/K+-ATPase from mouse brain. A hydrogen bond between the oxygen atom of Asp369 and the nitrogen atom of Lys690 plays a key role in maintaining the proper structure of the physphorylaton site in E1 conformation. Restraint-based comparative modeling was used for calculation and visualization of the H4-H5-loop of α2-isoform of Na+/K+-ATPase from mouse brain. A hydrogen bond between the oxygen atom of Asp369 and the nitrogen atom of Lys690 plays a key role in maintaining the proper structure of the physphorylaton site in E1 conformation. (en)
Title	Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation Počítačové modelování H4-H5-smyčky α2-isoformy α-podjednotky Na+/K+-ATPázy v E1 konformaci (cs) Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation (en)
skos:prefLabel	Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation Počítačové modelování H4-H5-smyčky α2-isoformy α-podjednotky Na+/K+-ATPázy v E1 konformaci (cs) Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation (en)
skos:notation	RIV/68378041:_____/07:00094849!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany	S143;S151
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(1ET400110403), P(2B06130), P(IAA500390702), V, Z(AV0Z50110509), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Tejral, Gracian Koláčná, Lucie Amler, Evžen
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	414248
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/07:00094849
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Computer modeling; Molecular dynamics simulations (en)
http://linked.open.../riv/klicoveSlovo	Computer modeling Molecular dynamics simulations
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[940F14642656]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Protein computer modeling and molecular dynamics simulation Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus. Scaffolds from liposome nanofibers for tissue engineering
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Amler, Evžen Koláčná, Lucie Kotyk, Arnošt Tejral, Gracian
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0862-8408
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation Comparative modeling of the H4-H5-loop of the α2-isoform of Na+/K+-ATPase α-subunit in the E1 conformation

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