About: Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aims: The diverse physiological functions of histamine are mediated through distinct histamine receptors. In this study we investigated the role of H2R and H4R in the effects of histamine on the production of reactive oxygen species by phagocytes in whole blood. Main methods: Changes in reactive oxygen species (ROS) production by whole blood phagocytes after treatment with histamine, H4R agonists (4-methylhistamine, VUF8430), H2R agonist (dimaprit) and their combinations with H4R antagonist (JNJ10191584) and H2R antagonist (ranitidine) were determined using the chemiluminescence (CL) assay. To exclude the direct scavenging effects of the studied compounds on the CL response, the antioxidant properties of all compounds were measured using several methods (TRAP, ORAC, and luminol-HRP-H2O2 based CL). Key findings: Histamine, 4-methylhistamine, VUF8430 and dimaprit inhibited the spontaneous and OZP-activated whole blood CL in a dose-dependent manner. Aims: The diverse physiological functions of histamine are mediated through distinct histamine receptors. In this study we investigated the role of H2R and H4R in the effects of histamine on the production of reactive oxygen species by phagocytes in whole blood. Main methods: Changes in reactive oxygen species (ROS) production by whole blood phagocytes after treatment with histamine, H4R agonists (4-methylhistamine, VUF8430), H2R agonist (dimaprit) and their combinations with H4R antagonist (JNJ10191584) and H2R antagonist (ranitidine) were determined using the chemiluminescence (CL) assay. To exclude the direct scavenging effects of the studied compounds on the CL response, the antioxidant properties of all compounds were measured using several methods (TRAP, ORAC, and luminol-HRP-H2O2 based CL). Key findings: Histamine, 4-methylhistamine, VUF8430 and dimaprit inhibited the spontaneous and OZP-activated whole blood CL in a dose-dependent manner. (en)
Title	Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes (en)
skos:prefLabel	Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes (en)
skos:notation	RIV/68081707:_____/14:00428666!RIV15-AV0-68081707
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(LD11010)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Lojek, Antonín Vašíček, Ondřej Číž, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	43124
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/14:00428666
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Histamine; Histamine receptors; Reactive oxygen species (en)
http://linked.open.../riv/klicoveSlovo	Reactive oxygen species Histamine Histamine receptors
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D045BE8EF3A9]
http://linked.open...i/riv/nazevZdroje	Life Sciences
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The effects of histamine receptor H4R antagonists on the production of reactive oxygen and nitrogen metabolites by phagocytes
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	100
http://linked.open...iv/tvurceVysledku	Lojek, Antonín Vašíček, Ondřej Jančinová, V. Číž, Milan Nosál, R.
http://linked.open...ain/vavai/riv/wos	000334323600009
issn	0024-3205
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.lfs.2014.01.082

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