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Description
| - Rezistence některých nádorových buněk k působení TRAILu je hlavní překážkou terapeutického využití tohoto cytokinu. Velkým přínosem v léčbě by mohla být kombinovaná terapie využívající látky schopné zcitlivět nádorové buňky k účinkům TRAILu. Mezi ně může patřit kyselina docosahexaenová. V naší studii jsme prokázali posílení buněčné smrti při současné aplikaci TRAILu a DHA a zabývali se příslušnými mechanismy. (cs)
- The resistance of some cancer cells to TRAIL-induced apoptosis is a major obstacle in successful clinical application of this cytokine. Combination treatment with agents capable of sensitising the cells to TRAIL effects is beneficial for new cancer treatment strategies. Docosahexaenoic acid (DHA) is under intense investigation for its ability to affect cancer cell growth and apoptosis. We demonstrated a modulation of TRAIL-induced apoptosis of HT-29 human colon cancer cells by DHA on the molecular (pro-caspase-3, -8, Bid, PARP cleavage) and cellular (cell viability and adhesion) level. To conclude, TRAIL and DHA were shown to cooperate in the induction of colon cancer cell apoptosis.
- The resistance of some cancer cells to TRAIL-induced apoptosis is a major obstacle in successful clinical application of this cytokine. Combination treatment with agents capable of sensitising the cells to TRAIL effects is beneficial for new cancer treatment strategies. Docosahexaenoic acid (DHA) is under intense investigation for its ability to affect cancer cell growth and apoptosis. We demonstrated a modulation of TRAIL-induced apoptosis of HT-29 human colon cancer cells by DHA on the molecular (pro-caspase-3, -8, Bid, PARP cleavage) and cellular (cell viability and adhesion) level. To conclude, TRAIL and DHA were shown to cooperate in the induction of colon cancer cell apoptosis. (en)
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Title
| - TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death
- TRAIL a kyselina docosahexaenová kooperují při indukci smrti nádorových buněk tlustého střeva HT-29 (cs)
- TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death (en)
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skos:prefLabel
| - TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death
- TRAIL a kyselina docosahexaenová kooperují při indukci smrti nádorových buněk tlustého střeva HT-29 (cs)
- TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death (en)
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skos:notation
| - RIV/68081707:_____/05:00024400!RIV06-AV0-68081707
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA524/03/0766), P(GA524/04/0895), Z(AV0Z50040507)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/05:00024400
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - TRAIL; DHA; cell death (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Anděra, Ladislav
- Hofmanová, Jiřina
- Kozubík, Alois
- Vaculová, Alena
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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