About: Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2.

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About: Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2. Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Inhibitors of arachidonic acid (AA) conversion were described as suppressors of proliferation and inducers of differentiation of various leukemic cells. Certain AA metabolites have been shown to cooperate with Jun proteins that are important factors controlling cell proliferation, differentiation and apoptosis. Using lipoxygenase (LOX) inhibitors of various specifity we studied possible participation of lipoxygenase pathway in regulation of proliferation and apoptosis of v-myb-transformed chicken monoblasts BM2 and its functional interaction with Jun proteins. We found that nordihydroguaiaretic acid (NDGA) and esculetin (Esc) negatively regulate proliferation of BM2 cells causing accumulation in either G(0)/G(1)-phase (nordihydroguaiaretic acid) or S-phase (esculetin) of the cell cycle. BM2 cells can be also induced to undergo growth arrest and partial differentiation by ectopic expression of Jun proteins. Inhibitors of arachidonic acid (AA) conversion were described as suppressors of proliferation and inducers of differentiation of various leukemic cells. Certain AA metabolites have been shown to cooperate with Jun proteins that are important factors controlling cell proliferation, differentiation and apoptosis. Using lipoxygenase (LOX) inhibitors of various specifity we studied possible participation of lipoxygenase pathway in regulation of proliferation and apoptosis of v-myb-transformed chicken monoblasts BM2 and its functional interaction with Jun proteins. We found that nordihydroguaiaretic acid (NDGA) and esculetin (Esc) negatively regulate proliferation of BM2 cells causing accumulation in either G(0)/G(1)-phase (nordihydroguaiaretic acid) or S-phase (esculetin) of the cell cycle. BM2 cells can be also induced to undergo growth arrest and partial differentiation by ectopic expression of Jun proteins. (en)
Title	Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2. Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2. (en)
skos:prefLabel	Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2. Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2. (en)
skos:notation	RIV/68081707:_____/03:17033137!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	131;145
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/01/0040), P(GA524/03/0766), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	3-4
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hofmanová, Jiřina Souček, Karel Pacherník, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	613659
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033137
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hematopoiesis; arachidonic acid; lipoxygenase inhibitors (en)
http://linked.open.../riv/klicoveSlovo	hematopoiesis lipoxygenase inhibitors arachidonic acid
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B975E9BDEDB1]
http://linked.open...i/riv/nazevZdroje	Prostaglandins and other Lipid Mediators
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The Role of Fos and Jun proteins in RA-driven monocytic differentiation Modulation of proliferation, differentiation and apoptosis of hemopoietic cells - interactions of cytokines, drugs and lipid nutrition compounds
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	72
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Kozubík, Alois Pacherník, Jiří Souček, Karel Sedláček, J. Šmarda, J. Bryja, V. Ševčíková, S. Zahradníčková, E.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0090-6980
number of pages	15 (xsd:int)

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