About: Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

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About: Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CD36 is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer. It also presents the view that CD36 and FA signaling coordinate fat utilization, a view that is based on newly identified CD36 actions that involve oral fat perception, intestinal fat absorption, secretion of the peptides cholecystokinin and secretin, regulation of hepatic lipoprotein output, activation of beta oxidation by muscle, and regulation of the production of the FA-derived bioactive eicosanoids CD36 is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer. It also presents the view that CD36 and FA signaling coordinate fat utilization, a view that is based on newly identified CD36 actions that involve oral fat perception, intestinal fat absorption, secretion of the peptides cholecystokinin and secretin, regulation of hepatic lipoprotein output, activation of beta oxidation by muscle, and regulation of the production of the FA-derived bioactive eicosanoids (en)
Title	Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism (en)
skos:prefLabel	Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism (en)
skos:notation	RIV/67985823:_____/14:00431311!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GP13-04449P)
http://linked.open...iv/cisloPeriodika	JULY
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kuda, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	47955
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00431311
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	fat taste; chylomicron; VLDL; CCK; secretin; calcium; FA binding; phospholipase; eicosanoid (en)
http://linked.open.../riv/klicoveSlovo	CCK FA binding VLDL chylomicron eicosanoid fat taste secretin calcium phospholipase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C0BE6F6E4A5E]
http://linked.open...i/riv/nazevZdroje	Annual Review of Nutrition
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Metabolism of eicosanoids in adipose tissue: molecular mechanisms with respect to fatty acid substrate
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Kuda, Ondřej Abumrad, N. A. Pepino, M. Y. Samovski, D.
http://linked.open...ain/vavai/riv/wos	000348455800012
issn	0199-9885
number of pages	22 (xsd:int)
http://bibframe.org/vocab/doi	10.1146/annurev-nutr-071812-161220

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