About: Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tocopheryl succinate (TOS), a redox-silent analogue of vitamin E, suppresses cell growth in a number of clinical and experimental cancers, inhibits mitochondrial dehydrogenase (SDH) and activates reactive oxygen species (ROS) generation. The aim of this study was to test whether TOS also inhibits glycerol-3-phosphate dehydrogenase (mGPDH), another flavoprotein-dependent enzyme of the mitochondrial respiratory chain because there are differences between electron transfer pathway from SDH and mGPDH to coenzyme Q pool. We found that TOS-induced inhibition of mGPDH is more pronounced than TOS-induced inhibition of SDH and that the inhibitory effect of TOS for both substrates is exerted at different location of the particular dehydrogenase. Our data indicate that the inhibition of mGPDH activity could also play a role in TOS-induced growth suppression in neoplastic cells Tocopheryl succinate (TOS), a redox-silent analogue of vitamin E, suppresses cell growth in a number of clinical and experimental cancers, inhibits mitochondrial dehydrogenase (SDH) and activates reactive oxygen species (ROS) generation. The aim of this study was to test whether TOS also inhibits glycerol-3-phosphate dehydrogenase (mGPDH), another flavoprotein-dependent enzyme of the mitochondrial respiratory chain because there are differences between electron transfer pathway from SDH and mGPDH to coenzyme Q pool. We found that TOS-induced inhibition of mGPDH is more pronounced than TOS-induced inhibition of SDH and that the inhibitory effect of TOS for both substrates is exerted at different location of the particular dehydrogenase. Our data indicate that the inhibition of mGPDH activity could also play a role in TOS-induced growth suppression in neoplastic cells (en)
Title	Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate (en)
skos:prefLabel	Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate (en)
skos:notation	RIV/67985823:_____/14:00431289!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP304/12/0259)
http://linked.open...iv/cisloPeriodika	AUG
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Drahota, Zdeněk Vokurková, Martina Rauchová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	21850
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00431289
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	brown adipose tissue mitochondria; oxygen consumption; glycerol-3-phosphate; succinate; reactive oxygen species (en)
http://linked.open.../riv/klicoveSlovo	brown adipose tissue mitochondria glycerol-3-phosphate oxygen consumption reactive oxygen species succinate
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[21EC6BB5FACE]
http://linked.open...i/riv/nazevZdroje	International Journal of Biochemistry and Cell Biology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Mutual interactions of various vasoactive systems, reactive oxygen species and G proteins in experimental hypertension
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Drahota, Zdeněk Rauchová, Hana Vokurková, Martina
http://linked.open...ain/vavai/riv/wos	000340340400047
issn	1357-2725
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.biocel.2014.06.010

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