About: Oxidative stress in immature brain following experimentally-induced seizures

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Status epilepticus (SE) induced in immature rats is associated with oxidative stress and mitochondrial dysfunction. Oxidative stress is apparently due to both the increased free radicals production and the limited antioxidant defense. Pronounced inhibition of mitochondrial complex I activity was demonstrated already during the acute phase of SE and it persists during long periods of survival following SE. The findings suggest that oxidative modification of the enzyme is most likely responsible for the sustained deficiency of complex I activity Status epilepticus (SE) induced in immature rats is associated with oxidative stress and mitochondrial dysfunction. Oxidative stress is apparently due to both the increased free radicals production and the limited antioxidant defense. Pronounced inhibition of mitochondrial complex I activity was demonstrated already during the acute phase of SE and it persists during long periods of survival following SE. The findings suggest that oxidative modification of the enzyme is most likely responsible for the sustained deficiency of complex I activity (en)
Title	Oxidative stress in immature brain following experimentally-induced seizures Oxidative stress in immature brain following experimentally-induced seizures (en)
skos:prefLabel	Oxidative stress in immature brain following experimentally-induced seizures Oxidative stress in immature brain following experimentally-induced seizures (en)
skos:notation	RIV/67985823:_____/13:00422469!RIV14-MSM-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA309/05/2015), P(GA309/08/0292), P(GAP302/10/0971), P(GAP303/10/0999), P(LL1204), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	Suppl.1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Folbergrová, Jaroslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	95088
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/13:00422469
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	immature rats; experimentally-induced seizures; oxidative stress; mitochondrial dysfunction; antioxidant defense (en)
http://linked.open.../riv/klicoveSlovo	experimentally-induced seizures immature rats mitochondrial dysfunction oxidative stress antioxidant defense
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F262CD65D4AC]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Post-injury angiogenesis in the immature brain Role of oxidative stress in brain injury following status epilepticus induced in immature rats The role of nitric oxide in experimentally induced seizures and epileptogenesis in rats. Study of potential protective effects of selected drugs on the development of epileptogenesis following status epilepticus induced in immature rats Genetic analysis of mitochondrial proteome: Integration of mitochondrial-nuclear epistasis with disease phenotypes in the rat
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Folbergrová, Jaroslava
http://linked.open...ain/vavai/riv/wos	000328901900004
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	10 (xsd:int)

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