About: Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter

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About: Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Disruption of BMH1 in S. cerevisiae, encoding the major 14-3-3 isoform, resulted in an increased sensitivity to Na+, Li+ and K+ and to cationic drugs. BMH1 deletion did not affect plasma membrane potential. Testing the genetic interaction between BMH genes and genes encoding five plasma-membrane potassium and sodium transporters revealed, that 14-3-3 proteins neither interact with the potassium uptake systems, nor with the potassium-specific channel nor with the Na+(K+)-ATPases. Instead, a genetic interaction was identified between BMH1 and NHA1 which encodes an Na+(K+)/H+ antiporter Disruption of BMH1 in S. cerevisiae, encoding the major 14-3-3 isoform, resulted in an increased sensitivity to Na+, Li+ and K+ and to cationic drugs. BMH1 deletion did not affect plasma membrane potential. Testing the genetic interaction between BMH genes and genes encoding five plasma-membrane potassium and sodium transporters revealed, that 14-3-3 proteins neither interact with the potassium uptake systems, nor with the potassium-specific channel nor with the Na+(K+)-ATPases. Instead, a genetic interaction was identified between BMH1 and NHA1 which encodes an Na+(K+)/H+ antiporter (en)
Title	Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter (en)
skos:prefLabel	Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter (en)
skos:notation	RIV/67985823:_____/12:00377359!RIV13-AV0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(IAA500110801), P(LC531), P(OC10012), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Sychrová, Hana Zahrádka, Jaromír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	181235
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00377359
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	yeast; 14-3-3 proteins; ion homeostasis; Nha1 antiporter (en)
http://linked.open.../riv/klicoveSlovo	yeast 14-3-3 proteins Nha1 antiporter ion homeostasis
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[6B98DB9795DB]
http://linked.open...i/riv/nazevZdroje	Biochimica et Biophysica Acta. General Subjects
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre on molecular biology and physiology of yeast communities Role of Na/H antiporters in cell physiology - transporters teamwork in intracellular pH and K+ homeostasis Transport of cations and protons across biomembranes - molecular structure and activity mechanism of Na+/H+ antiporter from lower eukaryotes
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	1820
http://linked.open...iv/tvurceVysledku	Sychrová, Hana Zahrádka, Jaromír Van Heusden, G.P.H.
http://linked.open...ain/vavai/riv/wos	000305366100007
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0304-4165
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbagen.2012.03.013
is http://linked.open...avai/riv/vysledek of	Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter

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