About: Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Six new arylpiperazinylbenzofurane derivatives as potential hybrid antihypertensive agents were designed and synthesized. The discussed compounds were prepared as free bases and subsequently they were transformed into hydrochloride salts. The position of preferential protonation of nitrogen in piperazine ring in hydrochloride salts was determined by means of IR spectra, 13C CP/MAS NMR spectra and 15N CP/MAS NMR spectra. These results were supported by ab initio/DFT calculations of partial charges and proton affinities. Physico-chemical properties of free bases and hydrochloride salts are discussed; especially partition and distributive coefficients log P and log D7.4, dissociation constants pKa, molecular surfaces and volumes. The experimental results were also subsequently correlated with ab initio/DFT calculations. film-coated tablets. Six new arylpiperazinylbenzofurane derivatives as potential hybrid antihypertensive agents were designed and synthesized. The discussed compounds were prepared as free bases and subsequently they were transformed into hydrochloride salts. The position of preferential protonation of nitrogen in piperazine ring in hydrochloride salts was determined by means of IR spectra, 13C CP/MAS NMR spectra and 15N CP/MAS NMR spectra. These results were supported by ab initio/DFT calculations of partial charges and proton affinities. Physico-chemical properties of free bases and hydrochloride salts are discussed; especially partition and distributive coefficients log P and log D7.4, dissociation constants pKa, molecular surfaces and volumes. The experimental results were also subsequently correlated with ab initio/DFT calculations. film-coated tablets. (en)
Title	Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents (en)
skos:prefLabel	Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents (en)
skos:notation	RIV/62157124:16370/09:00002074!RIV10-MSM-16370___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6046137305), Z(MSM6215712403)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Csöllei, Jozef Jampílek, Josef Opatřilová, R. Dohnal, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	345087
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/09:00002074
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Antihypertensive Agents; Synthesis; arylpiperazinylbenzofurane derivatives; hydrochloride salts; Physico-chemical properties; Hypertension; cardiovascular system (en)
http://linked.open.../riv/klicoveSlovo	Synthesis Antihypertensive Agents Physico-chemical properties arylpiperazinylbenzofurane derivatives hydrochloride salts Hypertension cardiovascular system
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[ADDDF89AEFED]
http://linked.open...i/riv/nazevZdroje	Current Organic Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Csöllei, Jozef Dohnal, Jiří Havlíček, Jaroslav Jampílek, Josef Pekárek, Tomáš Opatřilová, Radka Raich, Ivan Kačerová, Sandra
http://linked.open...ain/vavai/riv/wos	000268259200002
http://linked.open...n/vavai/riv/zamer	Teoretické základy potravinářských a biochemických technologií Active creation of health, yield and performance of the large animals
issn	1385-2728
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	16370
is http://linked.open...avai/riv/vysledek of	Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents

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