About: Novel roles of caspase-7 in cell differentiation during development of bones.

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About: Novel roles of caspase-7 in cell differentiation during development of bones. Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Caspases were primarily identified as the crucial molecules of the apoptotic machinery. Caspase-7 belongs to the group of executioner caspases (-3, -6, -7) ensuring the final phase of apoptosis. However, beyond minor group of apoptotic cells, activation of caspase-7 was detected also in large population of bone cells that did not show signs of apoptosis. Based on this observation, activation of caspase-7 was examined from early to postnatal stages of bone development to study its role during osteogenesis. Since the mechanisms of ossification in the intramembranous and endochondral bones may differ, our attention was paid to both models. Activation of caspase-7 was detected already in initial stages of bone formation and persisted to postnatal development in both systems. However, the effect of caspase-7 deficiency was manifested in dependence on type of ossification. Caspases were primarily identified as the crucial molecules of the apoptotic machinery. Caspase-7 belongs to the group of executioner caspases (-3, -6, -7) ensuring the final phase of apoptosis. However, beyond minor group of apoptotic cells, activation of caspase-7 was detected also in large population of bone cells that did not show signs of apoptosis. Based on this observation, activation of caspase-7 was examined from early to postnatal stages of bone development to study its role during osteogenesis. Since the mechanisms of ossification in the intramembranous and endochondral bones may differ, our attention was paid to both models. Activation of caspase-7 was detected already in initial stages of bone formation and persisted to postnatal development in both systems. However, the effect of caspase-7 deficiency was manifested in dependence on type of ossification. (en)
Title	Novel roles of caspase-7 in cell differentiation during development of bones. Novel roles of caspase-7 in cell differentiation during development of bones. (en)
skos:prefLabel	Novel roles of caspase-7 in cell differentiation during development of bones. Novel roles of caspase-7 in cell differentiation during development of bones. (en)
skos:notation	RIV/62157124:16170/14:43873324!RIV15-GA0-16170___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP502/12/1285)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Matalová, Eva
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Fakulta veterinárního lékařství
http://linked.open...dnocenehoVysledku	33112
http://linked.open...ai/riv/idVysledku	RIV/62157124:16170/14:43873324
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	osteogenesis; non-apoptotic roles; Caspase-7 (en)
http://linked.open.../riv/klicoveSlovo	Caspase-7 osteogenesis non-apoptotic roles
http://linked.open...ontrolniKodProRIV	[4C1AD25E6651]
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Apoptotic and non-apoptotic functions of caspases in hard tissue formation
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Vandenabeele, Peter Matalová, Eva Švandová, Eva Lesot, Hervé Berghe, Tom Vanden Tucker, Abigail Sharpe, Paul
http://localhost/t...ganizacniJednotka	16170

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