About: Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0734975012000079
Description	Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, D-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulation of biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield. Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, D-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulation of biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield. (en)
Title	Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids (en)
skos:prefLabel	Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids (en)
skos:notation	RIV/61989592:15310/13:33147803!RIV14-GA0-15310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0007/01/01), P(GAP501/12/0597)
http://linked.open...iv/cisloPeriodika	1 - SI
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hanosová, Helena Frébort, Ivo Frébortová, Jitka Galuszka, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	95372
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/13:33147803
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ergot alkaloids; production; genetic manipulation; biotechnology; Claviceps; Parasitic fungus (en)
http://linked.open.../riv/klicoveSlovo	Claviceps Parasitic fungus genetic manipulation production ergot alkaloids biotechnology
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A2B707A78464]
http://linked.open...i/riv/nazevZdroje	Biotechnology Advances
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Production of ergot alkaloid during the interaction of rye plant (Secale cereale) with fungus Claviceps purpurea Centre of the Region Haná for Biotechnological and Agricultural Research
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Frébort, Ivo Frébortová, Jitka Galuszka, Petr Hanosová, Helena
http://linked.open...ain/vavai/riv/wos	000315761200008
issn	0734-9750
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.biotechadv.2012.01.005
http://localhost/t...ganizacniJednotka	15310

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