About: Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds

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About: Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://adc.mef.hr/index.php/adc/article/view/1008
Description	Levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-alfa (TNF-alfa) may influence wound healing and wound closure in non-healing wounds. The aim of the study was to test the hypothesis that hydrogencalcium salts of oxidized cellulose change the production of matrix metalloproteinases (MMPs) and TNF-alfa, wound size and number of bacterial strains in non-healing wounds. We analyzed MMP-2, MMP-9 and TNF-alfa in the wound fluid from 20 patients by ELISA every fourteen days over six weeks. Wound size, pain, wound closure and bacterial strains in the wound were also investigated. The wound size was reduced in 14 patients and pain in 16 patients. Bacterial contamination of the wound decreased significantly after treatment. The level of MMP-2 correlated with TNF-alfa production. The level of MMP-9 was unchanged during the healing period. We conclude that hydrogencalcium salts of oxidized cellulose have a favorable effect on the reduction of bacterial contamination, wound size and pain. Levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-alfa (TNF-alfa) may influence wound healing and wound closure in non-healing wounds. The aim of the study was to test the hypothesis that hydrogencalcium salts of oxidized cellulose change the production of matrix metalloproteinases (MMPs) and TNF-alfa, wound size and number of bacterial strains in non-healing wounds. We analyzed MMP-2, MMP-9 and TNF-alfa in the wound fluid from 20 patients by ELISA every fourteen days over six weeks. Wound size, pain, wound closure and bacterial strains in the wound were also investigated. The wound size was reduced in 14 patients and pain in 16 patients. Bacterial contamination of the wound decreased significantly after treatment. The level of MMP-2 correlated with TNF-alfa production. The level of MMP-9 was unchanged during the healing period. We conclude that hydrogencalcium salts of oxidized cellulose have a favorable effect on the reduction of bacterial contamination, wound size and pain. (en)
Title	Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds (en)
skos:prefLabel	Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds (en)
skos:notation	RIV/61989592:15110/13:33146181!RIV14-MSM-15110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Ulrichová, Jitka Franková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	79797
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33146181
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxidized cellulose; chronic wound; TNF-alfa; MMP-9; MMP-2 (en)
http://linked.open.../riv/klicoveSlovo	oxidized cellulose chronic wound TNF-alfa MMP-2 MMP-9
http://linked.open...odStatuVydavatele	HR - Chorvatská republika
http://linked.open...ontrolniKodProRIV	[577CA6432A59]
http://linked.open...i/riv/nazevZdroje	Acta Dermatovenerologica Croatica
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Ulrichová, Jitka Franková, Jana Vrbková, Jana Diamantová, Dominika
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1330-027X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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