About: NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

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About: NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	NQO1 guards against oxidative stress and carcinogenesis and stabilizes p53. We find that a homozygous common missense variant (NQO12, rs1800566(T), NM_000903.2:c.558C4T) that disables NQO1 strongly predicts poor survival among two independent series of women with breast cancer (P 1/4 0.002, N 1/4 1,005; P 1/4 0.005, N 1/4 1,162), an effect particularly evident after anthracycline-based adjuvant chemotherapy with epirubicin (P 1/4 7.52 106) and in p53-aberrant tumors (P 1/4 6.15 105). Survival after metastasis was reduced among NQO12 homozygotes, further implicating NQO1 deficiency in cancer progression and treatment resistance. Consistently, response to epirubicin was impaired in NQO12-homozygous breast carcinoma cells in vitro, reflecting both p53-linked and p53 independent roles of NQO1. We propose a model of defective anthracycline response in NQO1-deficient breast tumors, along with increased genomic instability promoted by elevated reactive oxygen species (ROS), and suggest NQO1 guards against oxidative stress and carcinogenesis and stabilizes p53. We find that a homozygous common missense variant (NQO12, rs1800566(T), NM_000903.2:c.558C4T) that disables NQO1 strongly predicts poor survival among two independent series of women with breast cancer (P 1/4 0.002, N 1/4 1,005; P 1/4 0.005, N 1/4 1,162), an effect particularly evident after anthracycline-based adjuvant chemotherapy with epirubicin (P 1/4 7.52 106) and in p53-aberrant tumors (P 1/4 6.15 105). Survival after metastasis was reduced among NQO12 homozygotes, further implicating NQO1 deficiency in cancer progression and treatment resistance. Consistently, response to epirubicin was impaired in NQO12-homozygous breast carcinoma cells in vitro, reflecting both p53-linked and p53 independent roles of NQO1. We propose a model of defective anthracycline response in NQO1-deficient breast tumors, along with increased genomic instability promoted by elevated reactive oxygen species (ROS), and suggest (en)
Title	NAD(P)H:quinone oxidoreductase 1 NQO12 genotype (P187S) is a strong prognostic and predictive factor in breast cancer NAD(P)H:quinone oxidoreductase 1 NQO12 genotype (P187S) is a strong prognostic and predictive factor in breast cancer (en)
skos:prefLabel	NAD(P)H:quinone oxidoreductase 1 NQO12 genotype (P187S) is a strong prognostic and predictive factor in breast cancer NAD(P)H:quinone oxidoreductase 1 NQO12 genotype (P187S) is a strong prognostic and predictive factor in breast cancer (en)
skos:notation	RIV/61989592:15110/08:00009724!RIV10-MSM-15110___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bártek, Jiří Vrtěl, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	381478
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/08:00009724
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NQO1; oxidative stress; carcinogenesis; p53; breast cancer; treatment resistance (en)
http://linked.open.../riv/klicoveSlovo	breast cancer p53 treatment resistance oxidative stress carcinogenesis NQO1
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F44C377F6C1B]
http://linked.open...i/riv/nazevZdroje	Nature genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	22 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Bártek, Jiří Bartkova, Jiřina Blomqvist, Carl Nevanlinna, Heli Vrtěl, Radek Fagerholm1, Rainer Lukas, Jiří Tommiska, Johanna Aaltonen, Kirsimari Aittomäki, Kristiina Eskelinen, Matti Heikkilä, Päivi Hofstetter, Barbara Holli, Kaija Kallioniemi, Anne Kataja, Vesa Kilpivaara, Outi Kosma, Veli-Matti Mannermaa, Arto Syrjäkoski, Kirsi Uusitupa, Matti von Smitten, Karl
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1061-4036
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	NAD(P)H:quinone oxidoreductase 1 NQO12 genotype (P187S) is a strong prognostic and predictive factor in breast cancer NAD(P)H:quinone oxidoreductase 1 NQO12 genotype (P187S) is a strong prognostic and predictive factor in breast cancer NAD(P)H:quinone oxidoreductase 1 NQO12 genotype (P187S) is a strong prognostic and predictive factor in breast cancer NAD(P)H:quinone oxidoreductase 1 NQO12 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

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